An efficient synthesis of novel pyrano[2,3-d]- and furopyrano[2,3-d]pyrimidines via indium-catalyzed multi-component domino reaction
被引:33
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作者:
Prajapati, Dipak
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机构:
Reg Res Lab, Dept Med Chem, Jorhat, Assam, IndiaReg Res Lab, Dept Med Chem, Jorhat, Assam, India
Prajapati, Dipak
[1
]
Gohain, Mukut
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机构:
Reg Res Lab, Dept Med Chem, Jorhat, Assam, IndiaReg Res Lab, Dept Med Chem, Jorhat, Assam, India
Gohain, Mukut
[1
]
机构:
[1] Reg Res Lab, Dept Med Chem, Jorhat, Assam, India
来源:
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
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2006年
/
2卷
关键词:
D O I:
10.1186/1860-5397-2-11
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
Various novel pyrano [2,3-d] pyrimidines 5 and furopyrano [2,3-d] pyrimidines 7 were synthesized in 80-99% yields via a multicomponent domino Knoevenagel/ hetero-Diels-Alder reaction of 1,3dimethyl barbituric acid with an aromatic aldehyde and ethyl vinyl ether/2,3-dihydrofuran in presence of 1 mol% of indium(III) chloride. The reaction also proceeds in aqueous media without using any catalyst, but the yield is comparatively less (65-70%).
机构:
Korea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South KoreaKorea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South Korea
Bae, JW
Lee, SH
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Korea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South KoreaKorea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South Korea
Lee, SH
Cho, YJ
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Korea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South KoreaKorea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South Korea
Cho, YJ
Jung, YJ
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机构:
Korea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South KoreaKorea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South Korea
Jung, YJ
Hwang, HJ
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机构:
Korea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South KoreaKorea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South Korea
Hwang, HJ
Yoon, CM
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机构:
Korea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South KoreaKorea Univ, Grad Sch Biotechnol, Dept Life Sci & Biotechnol, Sungbuk Ku, Seoul 136701, South Korea