Attenuating Effect of Portulaca oleracea Extract on Chronic Constriction Injury Induced Neuropathic Pain in Rats: An Evidence of Anti-oxidative and Anti-inflammatory Effects

被引：28

作者：

Forouzanfar, Fatemeh ^{[1
]}

Hosseinzadeh, Hossein ^{[2
,3
]}

Khorrami, Mohammad B. ^{[4
]}

Asgharzade, Samira ^{[5
,6
]}

Rakhshandeh, Hassan ^{[7
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Neurosci, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran

[4] 17th Shahrivar Hosp, Social Secur Org, Mashhad, Razavi Khorasan, Iran

[5] Shahrekord Univ Med Sci, Cellular & Mol Res Ctr, Basic Hlth Sci Inst, Shahrekord, Iran

[6] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Mol Med, Shahrekord, Iran

[7] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2019年 / 18卷 / 04期

关键词：

Antinociceptive effect; antispasmodic; Portulaca oleracea; neuropathic pain; hyperalgesia; flavonoids; OXYGEN SPECIES ROS; PERIPHERAL NEUROPATHY; CENTRAL SENSITIZATION; SENSITIVE METHOD; L; MODEL; INTERLEUKIN-1-BETA; PHOSPHORYLATION; FLAVONOIDS; DISORDERS;

D O I：

10.2174/1871527318666190314110528

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Neuropathic pain responds poorly to drug treatments. The present study investigated the therapeutic effect of Portulaca oleracea, in chronic constriction injury (CCI)-induced neuropathic pain in rats. Objective & Methods: Neuropathic pain was performed by putting four loose ligatures around the sciatic nerve. CCI resulted in the development of heat hyperalgesia, mechanical allodynia and cold allodynia accompanied by an increase in the contents of TNF-alpha, IL1 beta, malondialdehyde, with a reduction in total thiol content. Results: Administration of Portulaca oleracea (100 and 200 mg/kg intraperitoneal) for 14 days in CCI rats significantly alleviated pain-related behaviors, oxidative damage and inflammatory cytokines in a dose-dependent manner. Conclusion: In conclusion, it is suggested that the antinociceptive effects of Portulaca oleracea might be due to antioxidant and anti-inflammatory properties.

引用

页码：342 / 349

页数：8

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