共 33 条
Histone Methylation Regulator PTIP Is Required for PPARγ and C/EBPα Expression and Adipogenesis
被引:121
作者:

Cho, Young-Wook
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NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA

Hong, SunHwa
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h-index: 0
机构:
NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA

Jin, Qihuang
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h-index: 0
机构:
NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA

Wang, Lifeng
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h-index: 0
机构:
NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA

Lee, Ji-Eun
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机构:
NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA

Gavrilova, Oksana
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDKD, Mouse Metab Core Lab, NIH, Bethesda, MD 20892 USA NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA

Ge, Kai
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA
机构:
[1] NIDDKD, Nucl Receptor Biol Sect, CEB, NIH, Bethesda, MD 20892 USA
[2] NIDDKD, Mouse Metab Core Lab, NIH, Bethesda, MD 20892 USA
关键词:
TRANSCRIPTIONAL CONTROL;
GENE;
CHROMATIN;
PROTEIN;
COACTIVATOR;
DOMAIN;
BETA;
FAT;
D O I:
10.1016/j.cmet.2009.05.010
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
PPAR gamma and C/EBP alpha cooperate to control preadipocyte differentiation (adipogenesis). However, the factors that regulate PPAR gamma and C/EBP alpha expression during adipogenesis remain largely unclear. Here, we show PTIP, a protein that associates with histone H3K4 methyltransferases, regulates PPAR gamma and C/EBP alpha expression in mouse embryonic fibroblasts (MEFs) and during preadipocyte differentiation. PTIP deletion in MEFs leads to marked decreases of PPAR gamma expression and PPAR gamma-stimulated C/EBP alpha expression. Further, PTIP is essential for induction of PPAR gamma and C/EBP alpha expression during preadipocyte differentiation. Deletion of PTIP impairs the enrichment of H3K4 trimethylation and RNA polymerase II on PPAR gamma and C/EBP alpha promoters. Accordingly, PTIP-/- MEFs and preadipocytes all show striking defects in adipogenesis. Rescue of the adipogenesis defect in PTIP-/- MEFs requires coexpression of PPAR gamma and C/EBP alpha. Finally, deletion of PTIP in brown adipose tissue significantly reduces tissue weight. Thus, by regulating PPAR gamma and C/EBP alpha expression, PTIP plays a critical role in adipogenesis.
引用
收藏
页码:27 / 39
页数:13
相关论文
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