Angiotensinogen T174M and M235T Variants and Hypertension in the Hani and Yi Minority Groups of China

被引：15
作者：
Yuan, Jiali [2 ]
Tang, Wenru [1 ]
Chun, Yinan [1 ]
Ying, Hua [2 ]
Yang, Yang [1 ]
Xiao, Chunjie [1 ]
机构：
[1] Yunnan Univ, Lab Conservat & Utilizat Bioresources, Ctr Human Genet, Kunming 650091, Peoples R China
[2] Yunnan Coll Tradit Chinese Med, Basic Med Sch, Kunming 650200, UT, Peoples R China
来源：
BIOCHEMICAL GENETICS | 2009年 / 47卷 / 5-6期
基金：
中国国家自然科学基金;
关键词：
Angiotensinogen; Hypertension; Hani population; Yi population; BLOOD-PRESSURE; ASSOCIATION ANALYSIS; CONVERTING-ENZYME; MOLECULAR-BASIS; GENE; POLYMORPHISM; RISK; POPULATION; LINKAGE; HAPLOTYPES;
D O I：
10.1007/s10528-009-9237-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A case-control study of 538 individuals investigated whether the angiotensinogen gene (AGT) might be implicated in the pathogenesis of essential hypertension in the Hani and Yi populations of China. Genotypes for two diallelic DNA polymorphisms observed at amino acid residues 174 (T174M) and 235 (M235T) within the coding sequence were determined. M235T and T174M genotyping with PCR-RFLP was performed in 267 normotensive subjects and 271 hypertensive subjects. No significant difference was found between normotensives and hypertensives in genotype distribution and allele frequency for either M235T or T174M in the Hani or the Yi populations (P > 0.05). Relative to carriers of the 235T/235T and 174T/174T combination, the others had a significantly elevated risk of hypertension (OR = 1.62, 95% CI 1.02-2.59; P = 0.043) in the Hani population. The AGT M235T and T174M variants in combination may play a role in the genetic predisposition to develop essential hypertension in the Hani minority of China.
引用
收藏
页码：344 / 350
页数：7
相关论文
共 50 条
  • [1] Angiotensinogen T174M and M235T Variants and Hypertension in the Hani and Yi Minority Groups of China
    Jiali Yuan
    Wenru Tang
    Yinan Chun
    Hua Ying
    Yang Yang
    Chunjie Xiao
    Biochemical Genetics, 2009, 47 : 344 - 350
  • [2] Blood pressure and the T174M and M235T polymorphisms of the angiotensinogen gene
    Niu, TH
    Chen, CZ
    Yang, JH
    Wang, BY
    Wang, ZX
    Schork, N
    Fang, Z
    Xu, XP
    ANNALS OF EPIDEMIOLOGY, 1999, 9 (04) : 245 - 253
  • [3] Investigation of Angiotensinogen M235T and T174M Gene Polymorphisms in Coronary Artery Disease
    Yamasan, Bilge Eren
    Gulyasar, Tevfik
    Sipahi, Tammam
    Sivri, Nasir
    Palabiyik, Orkide
    ERCIYES MEDICAL JOURNAL, 2021, 43 (05) : 475 - 481
  • [4] Gender-Related Association of AGT Gene Variants (M235T and T174M) with Essential Hypertension-A Case-Control Study
    Vamsi, Mohana U.
    Swapna, N.
    Reddy, Surender S.
    Vishnupriya, S.
    Padma, Tirunilai
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2012, 34 (01) : 38 - 44
  • [5] Angiotensinogen gene M235T and T174M polymorphisms in essential hypertension relation with target organ damage
    Fernández-Llama, P
    Poch, E
    Oriola, J
    Botey, A
    Rivera, F
    Revert, L
    AMERICAN JOURNAL OF HYPERTENSION, 1998, 11 (04) : 439 - 444
  • [6] Angiotensinogen Gene M235T and T174M Polymorphisms and Susceptibility of Pre-Eclampsia: A Meta-Analysis
    Lin, Rong
    Lei, Yunping
    Yuan, Ziyu
    Ju, Hongfang
    Li, Dongna
    ANNALS OF HUMAN GENETICS, 2012, 76 : 377 - 386
  • [7] Angiotensinogen T174M and M235T variants, sodium intake and hypertension among non-drinking, lean Japanese men and women
    Iso, H
    Harada, S
    Shimamoto, T
    Sato, S
    Kitamura, A
    Sankai, T
    Tanigawa, T
    Lida, M
    Komachi, Y
    JOURNAL OF HYPERTENSION, 2000, 18 (09) : 1197 - 1206
  • [8] Contribution of angiotensinogen M235T and T174M gene variants and haplotypes to preeclampsia and its severity in (North African) Tunisians
    Zitouni, Hedia
    Gannoum, Marwa Ben Ali
    Raguema, Nozha
    Maleh, Wided
    Zouari, Ines
    El Faleh, Raja
    Guibourdenche, Jean
    Almawi, Wassim Y.
    Mahjoub, Touhami
    JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2018, 19 (01)
  • [9] The genes polymorphism of angiotensinogen (AGT) M235T and AGT T174M in patients with essential hypertension: A meta-analysis
    Fajar, Jonny Karunia
    Pikir, Budi Susetio
    Sidarta, Erdo Puncak
    Saka, Putu Nina Berlinda
    Akbar, Rizal Rahmanda
    Tamara, Fredo
    Mayasari, Ema Dianita
    Gunawan, Atma
    Heriansyah, Teuku
    GENE REPORTS, 2019, 16
  • [10] Angiotensinogen gene polymorphisms M235T/T174M - No excess transmission to hypertensive Chinese
    Niu, TH
    Yang, JH
    Wang, BY
    Chen, W
    Wang, ZX
    Laird, N
    Wei, E
    Fang, Z
    Lindpaintner, K
    Rogus, JJ
    Xu, XP
    HYPERTENSION, 1999, 33 (02) : 698 - 702
12345