Effects of Kampo extracts on drug metabolism in rat liver microsomes:: Rhei Rhizoma extract and Glycyrrhizae Radix extract inhibit drug oxidation

被引：7

作者：

Hasegawa, A

Kawaguchi, Y

Nakasa, H

Nakamura, H

Ohmori, S

Ishii, I

Kitada, M

机构：

[1] Chiba Univ Hosp, Div Pharm, Chuo Ku, Chiba 2608677, Japan

[2] Chiba Univ, Fac Pharmaceut Sci, Lab Clin Pharmacol, Chiba 2638522, Japan

[3] Shinshu Univ Hosp, Dept Pharm, Matsumoto, Nagano 3908621, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2002年 / 89卷 / 02期

关键词：

Kampo; Japanese herbal medicine; drug oxidation; rat liver microsome;

D O I：

10.1254/jjp.89.164

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study, the effects on drug oxidations in rat liver microsomes in vitro using 126 Kampo extracts were investigated. Although the effects of inhibition on drug oxidations were dependent on the Kampo extracts and probe reactions studied, most of the Kampo extracts showed inhibitory effects on both N-demethylations of aminopyrine and erythromycin in rat liver microsomes. Among the Kampo extracts studied herein, Daio-kanzo-to exhibited the most remarkable inhibitory effect on both reactions. The Rhei Rhizoma extract inhibited not only aminopyrine and erythromycin N-demethylations, but also phenacetin O-deethylation, 7-ethoxycoumarin O-deethylation, ethanol oxidation and tolbutamide 4-hydroxylation in rat liver microsomes. The Glycyrrhizae Radix extract also showed a remarkable inhibitory effect on phenacetin O-deethylation as well as aminopyrine and erythromycin N-demethylations. In contrast, the Glycyrrhizae Radix extract virtually showed no effect on ethanol oxidation.

引用

页码：164 / 170

页数：7

共 31 条

[1] EFFECT OF GRAPEFRUIT JUICE AND NARINGIN ON NISOLDIPINE PHARMACOKINETICS [J].