Synthesis of 4,8-dimethoxy-1-naphthol via an acetyl migration

被引：7

作者：

Zhang, Qijing ^{[1
]}

Dong, Jinyun ^{[1
]}

Cui, Qing ^{[1
]}

Li, Shaoshun ^{[1
]}

Cui, Jiahua ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 06期

基金：

中国博士后科学基金;

关键词：

4-8-dimethoxy-1-naphthol; acetyl migration; juglone derivatives; EFFICIENT OXIDATIVE DIMERIZATION; COUPLING REACTION; ANTIBIOTICS; ANALOGS; 2,2'-BINAPHTHOL; NAPHTHOQUINONES; 1-NAPHTHOL; QUINONES;

D O I：

10.1080/00397911.2016.1199807

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on acetyl migration, an efficient synthesis of 4,8-dimethoxy-1-naphthol (1) has been achieved with high overall yield. Compared with the reported method, there were several advantages. First, the reaction conditions were mild. Second, the workup of each step was much simpler. Third, juglone as the starting material in the synthesis was readily available. The solvent and reaction temperature greatly influenced the migration process.

引用

页码：536 / 540

页数：5

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