Effects and Mechanisms of Tea and Its Bioactive Compounds for the Prevention and Treatment of Cardiovascular Diseases: An Updated Review

被引：78

作者：

Cao, Shi-Yu ^{[1
]}

Zhao, Cai-Ning ^{[1
]}

Gan, Ren-You ^{[2
]}

Xu, Xiao-Yu ^{[1
]}

Wei, Xin-Lin ^{[2
]}

Corke, Harold ^{[2
]}

Atanasov, Atanas G. ^{[3
,4
,5
]}

Li, Hua-Bin ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China

[3] Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Magdalenka, Poland

[4] Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, Austria

[5] Bulgarian Acad Sci, Inst Neurobiol, 23 Acad G Bonchev Str, BU-1113 Sofia, Bulgaria

来源：

ANTIOXIDANTS | 2019年 / 8卷 / 06期

基金：

国家重点研发计划;

关键词：

tea; bioactive compounds; polyphenols; EGCG; cardiovascular diseases; mechanisms; DENSITY-LIPOPROTEIN CHOLESTEROL; GREEN TEA; BLACK TEA; EPIGALLOCATECHIN GALLATE; OXIDATIVE STRESS; BLOOD-PRESSURE; DOUBLE-BLIND; ENDOTHELIAL DYSFUNCTION; COFFEE CONSUMPTION; PROSPECTIVE COHORT;

D O I：

10.3390/antiox8060166

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular diseases (CVDs) are critical global public health issues with high morbidity and mortality. Epidemiological studies have revealed that regular tea drinking is inversely associated with the risk of CVDs. Additionally, substantial in vitro and in vivo experimental studies have shown that tea and its bioactive compounds are effective in protecting against CVDs. The relevant mechanisms include reducing blood lipid, alleviating ischemia/reperfusion injury, inhibiting oxidative stress, enhancing endothelial function, attenuating inflammation, and protecting cardiomyocyte function. Moreover, some clinical trials also proved the protective role of tea against CVDs. In order to provide a better understanding of the relationship between tea and CVDs, this review summarizes the effects of tea and its bioactive compounds against CVDs and discusses potential mechanisms of action based on evidence from epidemiological, experimental, and clinical studies.

引用

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