VIROLOGY Host protein clips bird flu's wings in mammals

被引：2
作者：
Lowen, Anice C. [1 ]
机构：
[1] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
来源：
NATURE | 2016年 / 529卷 / 7584期
关键词：
MOLECULAR-BASIS; VIRUS; MUTATIONS; PB2; DETERMINANT; NP;
D O I：
10.1038/529030a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The polymerase enzyme from avian influenza A viruses does not function well in human cells. The protein ANP32A has been identified as the cellular factor mediating a major component of this host restriction. See Letter p.101
引用
收藏
页码：30 / 31
页数：3
相关论文
共 16 条
  • [1] Mutations to PB2 and NP Proteins of an Avian Influenza Virus Combine To Confer Efficient Growth in Primary Human Respiratory
    Danzy, Shamika
    Studdard, Lydia R.
    Manicassamy, Balaji
    Solorzano, Alicia
    Marshall, Nicolle
    Garcia-Sastre, Adolfo
    Steel, John
    Lowen, Anice C.
    [J]. JOURNAL OF VIROLOGY, 2014, 88 (22) : 13436 - 13446
  • [2] Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
    de Jong, Menno D.
    Simmons, Cameron P.
    Thanh, Tran Tan
    Hien, Vo Minh
    Smith, Gavin J. D.
    Chau, Tran Nguyen Bich
    Hoang, Dang Minh
    Chau, Nguyen Van Vinh
    Khanh, Truong Huu
    Dong, Vo Cong
    Qui, Phan Tu
    Van Cam, Bach
    Ha, Do Quang
    Guan, Yi
    Peiris, J. S. Malik
    Chinh, Nguyen Tran
    Hien, Tran Tinh
    Farrar, Jeremy
    [J]. NATURE MEDICINE, 2006, 12 (10) : 1203 - 1207
  • [3] Interaction of polymerase subunit PB2 and NP with importin α1 is a determinant of host range of influenza a virus
    Gabriel, Guelsah
    Herwig, Astrid
    Klenk, Hans-Dieter
    [J]. PLOS PATHOGENS, 2008, 4 (02)
  • [4] Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
    Hatta, M
    Gao, P
    Halfmann, P
    Kawaoka, Y
    [J]. SCIENCE, 2001, 293 (5536) : 1840 - 1842
  • [5] Identification, Characterization, and Natural Selection of Mutations Driving Airborne Transmission of A/H5N1 Virus
    Linster, Martin
    van Boheemen, Sander
    de Graaf, Miranda
    Schrauwen, Eefje J. A.
    Lexmond, Pascal
    Manz, Benjamin
    Bestebroer, Theo M.
    Baumann, Jan
    van Riel, Debby
    Rimmelzwaan, Guus F.
    Osterhaus, Albert D. M. E.
    Matrosovich, Mikhail
    Fouchier, Ron A. M.
    Herfst, Sander
    [J]. CELL, 2014, 157 (02) : 329 - 339
  • [6] Species difference in ANP32A underlies influenza A virus polymerase host restriction
    Long, Jason S.
    Giotis, Efstathios S.
    Moncorge, Olivier
    Frise, Rebecca
    Mistry, Bhakti
    James, Joe
    Morisson, Mireille
    Iqbal, Munir
    Vignal, Alain
    Skinner, Michael A.
    Barclay, Wendy S.
    [J]. NATURE, 2016, 529 (7584) : 101 - +
  • [7] Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells
    Maenz, Benjamin
    Brunotte, Linda
    Reuther, Peter
    Schwemmle, Martin
    [J]. NATURE COMMUNICATIONS, 2012, 3
  • [8] An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase
    Mehle, Andrew
    Doudna, Jennifer A.
    [J]. CELL HOST & MICROBE, 2008, 4 (02) : 111 - 122
  • [9] Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase
    Moncorge, Olivier
    Mura, Manuela
    Barclay, Wendy S.
    [J]. JOURNAL OF VIROLOGY, 2010, 84 (19) : 9978 - 9986
  • [10] The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza a H7N7 viruses
    Munster, Vincent J.
    de Wit, Emmie
    van Riel, Debby
    Beyer, Walter E. P.
    Rimmelzwaan, Guus F.
    Osterhaus, Albert D. M. E.
    Kuiken, Thijs
    Fouchier, Ron A. M.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2007, 196 (02) : 258 - 265
12