NOTCH SIGNALING AND INTESTINAL CANCER

被引：0
作者：
Guilmeau, Sandra [1 ]
机构：
[1] Univ Paris 05, Dept Endocrinol, Metab & Canc Inst Cochin, Paris, France
来源：
NOTCH SIGNALING IN EMBRYOLOGY AND CANCER | 2012年 / 727卷
关键词：
GAMMA-SECRETASE INHIBITOR; COLON-CANCER; STEM-CELLS; COLORECTAL-CANCER; GASTROINTESTINAL-TRACT; PROGENITOR CELLS; GENE-EXPRESSION; GOBLET CELLS; BETA-CATENIN; MOUSE INTESTINE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In recent years, a substantial body of evidence has accumulated to support the notion that signaling pathways known to be important during embryonic development play important roles in regulating self-renewing tissues and tumorigenesis. In this context, Notch signaling is now recognized as essential for maintaining progenitor/ stein cell population as well as for regulating cell lineage differentiation in the normal intestinal mucosa. Many studies have also showed that Notch signaling is constitutively activated in colorectal cancer and its inhibition is able to suppress the cell growth and sensitize cancer cells to treatment-induced apoptosis. Therefore, discovery of the role of gamma-secretase in the Notch signaling activation has prompted intensive research on the potential use of gamma-secretase inhibitors in the treatment of colon cancer. This chapter reviews the current understanding and research findings of the role of Notch signaling in intestinal homeostasis and colorectal cancer and discusses the possible Notch targeting approaches as novel molecular therapy for intestinal cancer.
引用
收藏
页码：272 / 288
页数：17
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