Graphene for multi-functional synthetic biology: The last 'zeitgeist' in nanomedicine

被引:38
作者
Servant, A. [1 ,2 ]
Bianco, A. [3 ]
Prato, M. [4 ]
Kostarelos, K. [1 ,2 ]
机构
[1] Univ Manchester, Nanomed Lab, Fac Med & Human Sci, Manchester M13 9PT, Lancs, England
[2] Univ Manchester, Natl Graphene Inst, Manchester M13 9PT, Lancs, England
[3] CNRS, Inst Biol Mol & Cellulaire, Lab Immunopathol & Chim Therapeut, F-67000 Strasbourg, France
[4] Univ Trieste, Dipartimento Sci Chim & Farmaceut, I-34127 Trieste, Italy
关键词
Nanotechnology; Nanomaterials; Drug delivery; Carbon; ELECTRON-TRANSFER; IN-VITRO; OXIDE; FUNCTIONALIZATION; DELIVERY; NANOPARTICLES; CHEMISTRY; THERAPY;
D O I
10.1016/j.bmcl.2014.01.051
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The high versatility of graphene has attracted significant attention in many areas of scientific research from electronics to physics and mechanics. One of the most intriguing utilisation of graphene remains however in nanomedicine and synthetic biology. In particular, the last decade has witnessed an exponential growth in the generation of novel candidate therapeutics of multiple biological activities based on graphene constructs with small molecules, such as anti-cancer drugs. In this Digest, we summarise the different synthetic strategies and routes available to fabricate these promising graphene conjugates and the opportunities for the design of multi-functional tools for synthetic biology that they offer. (C) 2014 The Authors. Published by Elsevier Ltd.
引用
收藏
页码:1638 / 1649
页数:12
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