MicroRNA-29a suppresses the growth, migration, and invasion of lung adenocarcinoma cells by targeting carcinoembryonic antigen-related cell adhesion molecule 6

被引：31
作者：
Han, Hye Sook [1 ]
Son, Seung-Myoung [2 ]
Yun, Jieun [3 ]
Jo, Yeong Nang [3 ]
Lee, Ok-Jun [2 ]
机构：
[1] Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju 361763, South Korea
[2] Chungbuk Natl Univ, Coll Med, Dept Pathol, Cheongju 361763, South Korea
[3] Korea Res Inst Biosci & Biotechnol, Bioevaluat Ctr, Cheongwon, South Korea
来源：
FEBS LETTERS | 2014年 / 588卷 / 20期
基金：
新加坡国家研究基金会;
关键词：
Carcinoembryonic antigen-related cell; adhesion molecule 6; Lung adenocarcinoma; MicroRNA; 29a; PANCREATIC ADENOCARCINOMA; CEACAM6; CANCER; FAMILY; EXPRESSION; MIR-29; OVEREXPRESSION; DETERMINANT; PROGRESSION; METASTASIS;
D O I：
10.1016/j.febslet.2014.08.023
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an important regulator of cell adhesion, invasion, and metastasis. The aim of this study was to evaluate the functional roles of CEACAM6 in lung adenocarcinoma and to identify miRNAs that inhibit the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. CEACAM6 expression is associated with poor prognosis of patients with lung adenocarcinoma, and CEACAM6 has important functional roles in controlling the growth, migration, and invasion of lung adenocarcinoma cells in vitro and in vivo. Furthermore, miR-29a can suppress the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. Therefore, miR-29a/CEACAM6 axis represents a potential therapeutic target for treatment of lung adenocarcinoma. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：3744 / 3750
页数：7
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