Vicinal Bisheterocyclizations of Alkynes via Nucleophilic Interception of a Catalytic Platinum Carbene

被引：36

作者：

Allegretti, Paul A. ^{[1
]}

Ferreira, Eric M. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 46期

关键词：

STEREOSELECTIVE-SYNTHESIS; HOMOPROPARGYLIC ALCOHOLS; GOLD; CYCLOISOMERIZATION; SPIROKETALS; ACETALS; KETONES; TETRAHYDROFURANS; REARRANGEMENTS; TRANSFORMATION;

D O I：

10.1021/ja408957a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel platinum-catalyzed double heterocyclization of propargylic ethers is described. The transformation exploits the intermediacy of a key alpha,beta-unsaturated carbene. The reactivity of this carbene is such that systems can be developed which avoid a complicating 1,2-hydrogen migration, allowing remarkable versatility in the selective syntheses of oxygen- and nitrogen-containing vicinal bis-heterocyclic compounds.

引用

页码：17266 / 17269

页数：4

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