Targeting KRAS-Mutant Non-Small-Cell Lung Cancer: One Mutation at a Time, With a Focus on KRAS G12C Mutations

被引:39
|
作者
Burns, Timothy F. [1 ]
Borghaei, Hossein [2 ]
Ramalingam, Suresh S. [3 ]
Mok, Tony S. [4 ]
Peters, Solange [5 ]
机构
[1] Univ Pittsburgh Med Ctr UPMC, Hillman Canc Ctr, Pittsburgh, PA USA
[2] Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA
[3] Emory Univ, Sch Med, Winship Canc Inst, Div Med Oncol, Atlanta, GA USA
[4] Chinese Univ Hong Kong, Dept Clin Oncol, State Lab Translat Oncol, Hong Kong, Peoples R China
[5] Lausanne Univ, Dept Oncol, Ctr Hosp Univ Vaudois, Lausanne, Switzerland
关键词
SELUMETINIB PLUS DOCETAXEL; PROGRESSION-FREE SURVIVAL; K-RAS MUTATIONS; SELECTIVE-INHIBITION; PREDICTIVE-VALUE; CHINESE PATIENTS; POOLED ANALYSIS; MEK INHIBITORS; NEVER SMOKERS; WILD-TYPE;
D O I
10.1200/JCO.20.00744
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:4208 / 4218
页数:14
相关论文
共 50 条
  • [1] KRAS G12C mutations in non-small cell lung cancer
    Li, J. J.
    Wu, X. J.
    Farzin, M.
    Bray, V.
    Williamson, J.
    Pal, A.
    Yip, P. Y.
    Hagelamin, A.
    Ding, P.
    Nindra, U.
    Vinod, S.
    French, B.
    Chua, W.
    Gupta, R.
    Cooper, W. A.
    Wang, B.
    Lee, C. S.
    HISTOPATHOLOGY, 2024, 85 : 25 - 25
  • [2] Targeting KRAS G12C mutation in lung adenocarcinoma
    Rohatgi, Anjali
    Govindan, Ramaswamy
    LUNG CANCER, 2022, 165 : 28 - 33
  • [3] Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ
    Lee, Wen-Ying
    Chen, Pin-Cyuan
    Wu, Wen-Shin
    Wu, Han-Chung
    Lan, Chun-Hsin
    Huang, Yen-Hua
    Cheng, Chia-Hsiung
    Chen, Ku-Chung
    Lin, Cheng-Wei
    INTERNATIONAL JOURNAL OF CANCER, 2017, 141 (09) : 1921 - 1931
  • [4] Sotorasib: a treatment for non-small cell lung cancer with the KRAS G12C mutation
    Zheng, Xinting
    Luo, Jiamin
    Liu, Wei
    Ashby, Charles R., Jr.
    Chen, Zhe-Sheng
    Lin, Lizhu
    DRUGS OF TODAY, 2022, 58 (04) : 175 - 185
  • [5] Targeting KRAS G12C mutations in colorectal cancer
    Zhao, Ming-He
    Wu, Ai-Wen
    GASTROENTEROLOGY REPORT, 2023, 11
  • [6] Efficacy of immunotherapy in KRAS-mutant non-small-cell lung cancer with comutations
    Davis, Alexander P.
    Cooper, Wendy A.
    Boyer, Michael
    Lee, Jenny H.
    Pavlakis, Nick
    Kao, Steven C.
    IMMUNOTHERAPY, 2021, 13 (11) : 941 - 952
  • [7] Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition
    Tereza Vaclova
    Atanu Chakraborty
    James Sherwood
    Sarah Ross
    Danielle Carroll
    J. Carl Barrett
    Julian Downward
    Elza C. de Bruin
    Scientific Reports, 12
  • [8] Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition
    Vaclova, Tereza
    Chakraborty, Atanu
    Sherwood, James
    Ross, Sarah
    Carroll, Danielle
    Barrett, J. Carl
    Downward, Julian
    de Bruin, Elza C.
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [9] Clinical and Imaging Features of Non-Small Cell Lung Cancer with G12C KRAS Mutation
    Wu, Markus Y.
    Zhang, Eric W.
    Strickland, Matthew R.
    Mendoza, Dexter P.
    Lipkin, Lev
    Lennerz, Jochen K.
    Gainor, Justin F.
    Heist, Rebecca S.
    Digumarthy, Subba R.
    CANCERS, 2021, 13 (14)
  • [10] Targeting WEE1 to improve the therapy of KRAS G12C mutant non-small cell lung cancer
    Yamamoto, Gaku
    Tanaka, Kosuke
    Kamata, Ryo
    Mori, Shunta
    Liu, Jie
    Yamauchi, Toyohiro
    Sakae, Yuta
    Ohashi, Akihiro
    Kobayashi, Susumu S.
    CANCER RESEARCH, 2023, 83 (07)