Genomic alterations in diffuse-type gastric cancer as shown by high-resolution comparative genomic hybridization

被引：16
作者：
Takeno, Sylvia Satomi [1 ]
Leal, Mariana Ferreira [1 ]
Frias Lisboa, Luara Carolina [1 ]
Nunes Lipay, Monica Vannucci [1 ]
Khayat, Andre Salim [2 ]
Assumpcao, Paulo Pimentel [3 ]
Burbano, Rommel Rodriguez [2 ]
Cardoso Smith, Marilia de Arruda [1 ]
机构：
[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Div Genet, BR-04023900 Sao Paulo, Brazil
[2] Inst Biol Sci, Human Cytogenet Lab, BR-66075900 Belem, Para, Brazil
[3] Joao de Barros Barreto Univ Hosp, BR-66073000 Belem, Para, Brazil
来源：
CANCER GENETICS AND CYTOGENETICS | 2009年 / 190卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
IN-SITU HYBRIDIZATION; C-MYC AMPLIFICATION; NORTHERN BRAZIL; GENETIC ALTERATIONS; INTESTINAL-TYPE; COPY-NUMBER; CHROMOSOMAL IMBALANCES; HISTOLOGIC SUBTYPES; TUMOR PROGRESSION; CELL-LINES;
D O I：
10.1016/j.cancergencyto.2008.09.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric adenocarcinoma is a serious public health concern, especially in northern Brazil. Gastric cancer call be subdivided into diffuse and intestinal types. Genetic imbalances in diffuse-type gastric cancer remain largely unknown. In the present study, we analyzed 24 advanced diffuse-type gastric cancer samples from northern Brazil subjects using high-resolution comparative genomic hybridization. We found chromosomal alterations in 75% of samples. In cancers with aneusomies, the mean genomic copy number alteration was 6.4. Losses of chromosome regions exceeded gains. The most frequent losses were located at chromosome regions 11q and 18q (five samples for each region), 1pq, 3q, 4q, 5q, 13q, and 14q (four samples), followed by 2pq, 7p, 9pq, 11p, and 16p (three Samples). Our results confirm that gastric cancer has a complex pattern of chromosomal alterations that call he clue to general chromosomal instability related to the advanced stage of gastric carcinogenesis. Loss of 11q and 18q were the most frequent chromosomal changes in diffuse-type gastric adenocarcinoma in individuals from northern Brazil. Frequent loss of 11q chromosome region in this gastric cancer may be peculiar among this population. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：1 / 7
页数：7
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