Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives

被引：20

作者：

Fujisaki, Fumiko ^{[1
]}

Aki, Hatsumi ^{[1
]}

Naito, Ayumi ^{[1
]}

Fukami, Enko ^{[1
]}

Kashige, Nobuhiro ^{[1
]}

Miake, Fumio ^{[1
]}

Sumoto, Kunihiro ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2014年 / 62卷 / 05期

关键词：

hydantoin; regioselective; antibacterial activity; isothermal titration calorimetry; bivalent twin-drug; sulfated glycosaminoglycan; ANTIBACTERIAL ACTIVITY; CHEMICAL-PROPERTIES; 5-DIALKYLAMINOMETHYLHYDANTOINS; OXAZOLIDINONES;

D O I：

10.1248/cpb.c14-00017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In connection with our studies on hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene hydantoins 4a-c to 5-aminomethyl-substituted hydantoins 5-10 or to 5-amino-5-methyl-disubstituted hydantoins 11-14 is described. Synthesis of bivalent twin-drug type hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical hydantoin derivative 24b to sulfated glycosaminoglycans are also described.

引用

页码：429 / 438

页数：10

共 27 条

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