Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives

被引：20
作者：
Fujisaki, Fumiko [1 ]
Aki, Hatsumi [1 ]
Naito, Ayumi [1 ]
Fukami, Enko [1 ]
Kashige, Nobuhiro [1 ]
Miake, Fumio [1 ]
Sumoto, Kunihiro [1 ]
机构：
[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2014年 / 62卷 / 05期
关键词：
hydantoin; regioselective; antibacterial activity; isothermal titration calorimetry; bivalent twin-drug; sulfated glycosaminoglycan; ANTIBACTERIAL ACTIVITY; CHEMICAL-PROPERTIES; 5-DIALKYLAMINOMETHYLHYDANTOINS; OXAZOLIDINONES;
D O I：
10.1248/cpb.c14-00017
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In connection with our studies on hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene hydantoins 4a-c to 5-aminomethyl-substituted hydantoins 5-10 or to 5-amino-5-methyl-disubstituted hydantoins 11-14 is described. Synthesis of bivalent twin-drug type hydantoin derivatives 19-24 and the binding property of a bivalent symmetrical hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
引用
收藏
页码：429 / 438
页数：10
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