Somatic recombination, gene amplification and cancer

被引：30
作者：
Ramel, C
Cederberg, H
Magnusson, J
Vogel, E
Natarajan, AT
Mullender, LH
Nivard, JM
Parry, JM
Leyson, A
Comendador, MA
Sierra, LM
Ferreiro, JA
Consuegra, S
机构：
[1] LEIDEN STATE UNIV,DEPT RADIAT GENET & CHEM MUTAGENESIS,2312 AV LEIDEN,NETHERLANDS
[2] UNIV COLL SWANSEA,SCH BIOL SCI,SWANSEA SA2 8PP,W GLAM,WALES
[3] UNIV OVIEDO,DEPT FUNCT BIOL,OVIEDO,SPAIN
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 353卷 / 1-2期
关键词：
D O I：
10.1016/0027-5107(95)00243-X
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The principle objective of this research programme, to analyse chemical induction of somatic recombination and related endpoints, e.e., mobilization of transposing elements and gene amplification, has been approached by means of several assay systems. These have included Drosophila, Saccharomyces and mammalian cell cultures.
引用
收藏
页码：85 / 107
页数：23
相关论文
共 34 条
[1]   CHEMICALLY-INDUCED CHANGES IN THE SPECTRUM OF AMPLIFICATIONS OF THE HUMAN MINISATELLITE MS1 INTEGRATED IN CHROMOSOME-III OF A HAPLOID YEAST-STRAIN [J].
AGURELL, E ;
CEDERBERG, H ;
HEDENSKOG, M ;
RANNUG, U .
MOLECULAR & GENERAL GENETICS, 1994, 242 (02) :137-144
[2]   GENOTOXIC EFFECTS OF ETHYLENE-OXIDE AND PROPYLENE-OXIDE - A COMPARATIVE-STUDY [J].
AGURELL, E ;
CEDERBERG, H ;
EHRENBERG, L ;
LINDAHLKIESSLING, K ;
RANNUG, U ;
TORNQVIST, M .
MUTATION RESEARCH, 1991, 250 (1-2) :229-237
[3]   DETERMINATION OF THE GENOTOXIC STATUS OF A CHEMICAL [J].
ASHBY, J .
MUTATION RESEARCH, 1991, 248 (02) :221-231
[4]  
ASHBY J, 1988, EVALUATION SHORT TER
[5]  
ASHBY J, 1985, PROGR MUTATION RES, V5, P1
[6]  
BROOKS TM, 1993, GENOTOXICOLOGY STUDI
[7]   AMPLIFICATION AND LOSS OF REPEAT UNITS OF THE HUMAN MINISATELLITE MS1 INTEGRATED IN CHROMOSOME-III OF A HAPLOID YEAST-STRAIN [J].
CEDERBERG, H ;
AGURELL, E ;
HEDENSKOG, M ;
RANNUG, U .
MOLECULAR & GENERAL GENETICS, 1993, 238 (1-2) :38-42
[8]   POLY(ADP-RIBOSE)POLYMERASE - A PERPLEXING PARTICIPANT IN CELLULAR-RESPONSES TO DNA BREAKAGE [J].
CLEAVER, JE ;
MORGAN, WF .
MUTATION RESEARCH, 1991, 257 (01) :1-18
[9]  
CONSUEGRA SA, 1995, IN PRESS MUTATION RE
[10]   MODULATING INFLUENCE OF INORGANIC ARSENIC ON THE RECOMBINOGENIC AND MUTAGENIC ACTION OF IONIZING-RADIATION AND ALKYLATING-AGENTS IN DROSOPHILA-MELANOGASTER [J].
DELAROSA, ME ;
MAGNUSSON, J ;
RAMEL, C ;
NILSSON, R .
MUTATION RESEARCH-REVIEWS IN GENETIC TOXICOLOGY, 1994, 318 (01) :65-71
1234