Incretin Therapy and Heart Failure

被引:12
作者
Oyama, Jun-ichi [1 ]
Node, Koichi [2 ]
机构
[1] Saga Univ, Dept Adv Cardiol, Fac Med, Saga 8498501, Japan
[2] Saga Univ, Dept Cardiovasc Med, Fac Med, Saga 8498501, Japan
关键词
DPP-4; inhibitor; GLP-1; Heart failure; Incretin; Type 2 diabetes mellitus (T2DM); GLUCAGON-LIKE PEPTIDE-1; ISCHEMIA-REPERFUSION INJURY; MYOCARDIAL GLUCOSE-UPTAKE; LEFT-VENTRICULAR PERFORMANCE; NITRIC-OXIDE; CARDIAC-FUNCTION; CONSCIOUS DOGS; RECEPTOR AGONIST; DPP-4; INHIBITION; GLYCEMIC CONTROL;
D O I
10.1253/circj.CJ-13-1561
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Type 2 diabetes mellitus (T2DM) is widely prevalent and a critical risk factor for cardiovascular disease that increases both morbidity and mortality. Recently, new therapies based on the actions of the incretin hormones have become widely used, offering advantages over conventional treatments by limiting hypoglycemia and achieving glycemic control. Moreover, many experimental studies have suggested that GLP-1 and related drugs exert cardioprotective effects on atherosclerosis and cardiac dysfunction both in vitro and in vivo. However, there is thus far little clinical evidence supporting the efficacy of incretin therapy in patients with cardiovascular disease. This review focuses on the effects of GLP-1-related therapy on cardiac function from the bench to the bed, with a discussion of possible underlying mechanisms.
引用
收藏
页码:819 / 824
页数:6
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