Cytotoxic Constituents from Vietnamese Marine Sponge Haliclona oculata (Linnaeus, 1759)

被引：3
|
作者：
Phan Van Kiem [1 ]
Nguyen Thi Viet Thanh [3 ]
Dan Thi Thuy Hang [1 ]
Nguyen Thi Cuc [1 ]
Nguyen Xuan Nhiem [1 ]
Pham Hai Yen [1 ]
Hoang Le Tuan Anh [1 ]
Bui Huu Tai [1 ]
Do Thi Thao [2 ]
Chau Van Minh [1 ]
机构：
[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam
[2] VAST, Inst Biochem, Hanoi, Vietnam
[3] Hanoi Univ Sci & Technol, Sch Chem Engn, Hanoi, Vietnam
来源：
LETTERS IN ORGANIC CHEMISTRY | 2015年 / 12卷 / 10期
关键词：
Brominated lipid; cytotoxic; Haliclona oculata; steroid; NATURAL-PRODUCTS; STEROLS;
D O I：
10.2174/1570178612999150923120855
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Using various chromatography methods, five steroids and two brominated lipids (1-7), 3 beta-hydroxy-5-cholenic acid methyl ester, stigmasta-5,24(28)-dien-3 beta,29-diol, 24-methylenecholest-4-en-3 beta,6 beta-diol, cholest-5-en-3 beta,7 beta-diol, 24-vinylcholest-5-en-3 beta,24-diol, xestospongiene A, and xestospongiene J, respectively, were isolated from the methanol extract of Vietnamese marine sponge Haliclona oculata (Linnaeus, 1759). Their structures were elucidated by 1D-, 2D-NMR, and ESI-MS spectra and in comparison with those reported in the literature. Compounds 1-4, 6, and 7 were reported from Chalinidae family for the first time. In addition, all compounds were evaluated for eight human cancer cell lines as HepG-2, KB, LU-1, MCF-7, LNCaP, HL-60, SK-Mel2, and PC-3. As shown in results, compound 2 showed significant cytotoxic activities on KB and LU-1 cancer cell lines with the IC50 values ranging from 8.74 to 9.32 mu M.
引用
收藏
页码：708 / 712
页数：5
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