A Time Frame for Testing Negative for SARS-COV2 in People with Obesity

被引:7
作者
Dicker, Dror [1 ,2 ]
Lev, Shaul [3 ]
Gottesman, Tamar [4 ]
Kournos, Tatiana [1 ]
Dotan, Maya [1 ]
Ashorov, Nina [1 ]
Marcoviciu, Dana [1 ]
Golan, Rachel [5 ]
机构
[1] Rabin Med Ctr, Hasharon Hosp, Dept Internal Med D, 7 Keren Kayemet St, IL-49100 Petah Tiqwa, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Ramat Aviv, Israel
[3] Rabin Med Ctr, Hasharon Hosp, Intens Care Unit, Petah Tiqwa, Israel
[4] Rabin Med Ctr, Hasharon Hosp, Dept Infect Dis & Infect Control Serv, Petah Tiqwa, Israel
[5] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Publ Hlth, Beer Sheva, Israel
关键词
Obesity; Overweight; SARS-COV2; IMPACT;
D O I
10.1159/000511738
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Obesity is a major risk factor for becoming seriously ill with the 2019 novel coronavirus (COVID-19). One difficulty faced by clinicians and by patients is the unknown time frame of hospitalization until discharge of symptomatic patients. Methods: We followed 34 patients with laboratory-confirmed COVID-19 infection who recovered fromthe infection. All diagnoses were given using semi-quantitative RT-PCR on nasopharyngeal swabs. Envelope protein gene (E), RNA-dependent RNA polymerase gene (RdRP), and nucleocapsid gene (N) were measured by RT-PCR. Weight was measured and height was self-reported. Results: Mean +/- SD age was 51.8 +/- 16.7 years. Mean +/- SD body mass index (BMI) was 27.4 +/- 4.7 kg/m(2). 26% (9/34) had obesity, with BMI above 30 kg/m(2). Fifteen patients had BMI between 25 and 29.9 kg/m(2). The mean length of hospital stay was longer for those with a BMI >25 kg/m(2) (n = 24) than for those with a normal BMI (19.2 vs. 16.0 days, p = 0.08). Comparing people with obesity (BMI >30 kg/m(2) or above) to those without obesity, the difference was larger (20.6 vs. 16.0 days, p = 0.06). A trend for correlation between body weight and the time to negative detection of RdRp gene was found (r = 0.33, p = 0.09). Conclusions: Our results highlight the need for priority of early detection and testing, and early therapy for people with obesity and COVID-19 infections.
引用
收藏
页码:528 / 533
页数:6
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