Targeting Candida spp. to develop antifungal agents

被引：25

作者：

Salci, Tania P. ^{[1
,2
]}

Negri, Melyssa ^{[1
]}

Abadio, Ana K. R. ^{[3
]}

Svidzinski, Terezinha I. E. ^{[1
]}

Kioshima, Erika S. ^{[1
]}

机构：

[1] Univ Estadual Maringa, Av Colombo 5-790 Jd Univ, BR-87020900 Maringa, Parana, Brazil

[2] Ctr Univ Integrado, Rodovia BR 158,Km 207, BR-87300970 Campo Mourao, Parana, Brazil

[3] Univ Estado Mato Grosso, Campus Nova Xavantina, BR-78690000 Nova Xavantina, Mato Grosso, Brazil

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 04期

关键词：

RESPONSE REGULATOR GENE; CHITIN SYNTHASE GENE; PHOSPHOLIPASE-B GENE; MDR1 EFFLUX PUMP; REDUCED ECHINOCANDIN SUSCEPTIBILITY; MAJOR FACILITATOR SUPERFAMILY; AZOLE RESISTANCE MECHANISMS; CELL-WALL INTEGRITY; SACCHAROMYCES-CEREVISIAE; FLUCONAZOLE RESISTANCE;

D O I：

10.1016/j.drudis.2018.01.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Invasive fungal infections are a complex challenge throughout the world because of their high incidence, mainly in critically ill patients, and high mortality rates. The antifungal agents currently available are limited; thus, there is a need for the rapid development of new drugs. In silico methods are a modern strategy to explore interactions between new compounds and specific fungal targets, but they depend on precise genetic information. Here, we discuss the main Candida spp. target genes, including information about null mutants, virulence, cytolocalization, co-regulatory genes, and compounds that are related to protein expression. These data will provide a basis for the future in silico development of antifungal drugs.

引用

页码：802 / 814

页数：13

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