Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer's disease continuum

被引：12

作者：

Toledo, Jon B. ^{[1
]}

Liu, Hangfan ^{[2
]}

Grothe, Michel J. ^{[3
]}

Rashid, Tanweer ^{[2
,4
,5
]}

Launer, Lenore ^{[6
]}

Shaw, Leslie M. ^{[7
]}

Snoussi, Haykel ^{[4
,5
]}

Heckbert, Susan ^{[8
,9
,10
,11
,12
]}

Weiner, Michael ^{[13
,14
,15
]}

Trojanwoski, John Q. ^{[7
,16
]}

Seshadri, Sudha ^{[17
,18
]}

Habes, Mohamad ^{[2
,4
,5
]}

机构：

[1] Univ Florida, Coll Med, Dept Neurol, Gainesville, FL 32611 USA

[2] Univ Penn, Ctr Biomed Image Comp & Analyt CBICA, Philadelphia, PA 19104 USA

[3] Univ Seville, Hosp Univ Virgen del Rocio, CSIC, Unidad Trastornos Movimiento,Inst Bioedicina Sevi, Seville, Spain

[4] Univ Texas Hlth Sci Ctr San Antonio UTHSCSA, Neuroimage Analyt Lab NAL, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA

[5] Univ Texas Hlth Sci Ctr San Antonio UTHSCSA, Biggs Inst Neuroimaging Core BINC, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA

[6] NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, Bethesda, MD 20892 USA

[7] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[8] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[9] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[10] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA

[11] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[12] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[13] US Dept Vet Affairs, Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA USA

[14] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[15] Univ Penn, Alzheimers Dis Core Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA

[16] Univ Penn, Inst Aging, Perelman Sch Med, Philadelphia, PA 19104 USA

[17] Univ Penn, Perelman Sch Med, Udall Parkinsons Res Ctr, Philadelphia, PA 19104 USA

[18] Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2022年 / 8卷 / 01期

关键词：

Alzheimer's disease; amyloid beta; heterogeneity; mangetic resonance imaging; positron emission tomography; prognosis; tau; WHITE-MATTER HYPERINTENSITIES; DEFINED SUBTYPES; CEREBROVASCULAR-DISEASE; CEREBROSPINAL-FLUID; PATTERNS; PROGRESSION; BIOMARKERS; COGNITION; FEATURES;

D O I：

10.1002/trc2.12305

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Neuroimaging heterogeneity in dementia has been examined using single modalities. We evaluated the associations of magnetic resonance imaging (MRI) atrophy and flortaucipir positron emission tomography (PET) clusters across the Alzheimer's disease (AD) spectrum. Methods We included 496 Alzheimer's Disease Neuroimaging Initiative participants with brain MRI, flortaucipir PET scan, and amyloid beta biomarker measures obtained. We applied a novel robust collaborative clustering (RCC) approach on the MRI and flortaucipir PET scans. We derived indices for AD-like (SPARE-AD index) and brain age (SPARE-BA) atrophy. Results We identified four tau (I-IV) and three atrophy clusters. Tau clusters were associated with the apolipoprotein E genotype. Atrophy clusters were associated with white matter hyperintensity volumes. Only the hippocampal sparing atrophy cluster showed a specific association with brain aging imaging index. Tau clusters presented stronger clinical associations than atrophy clusters. Tau and atrophy clusters were partially associated. Conclusions Each neuroimaging modality captured different aspects of brain aging, genetics, vascular changes, and neurodegeneration leading to individual multimodal phenotyping.

引用

页数：14

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