Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case

被引：2

作者：

Nakano, Shogo ^{[1
]}

Minaga, Kosuke ^{[1
,2
]}

Tani, Yasuhiro ^{[1
]}

Tonomura, Kohei ^{[1
]}

Hanawa, Yusuke ^{[1
]}

Morimura, Hiroki ^{[1
]}

Terashita, Tomoko ^{[1
]}

Matsumoto, Hisakazu ^{[1
]}

Iwagami, Hiroyoshi ^{[1
]}

Nakatani, Yasuki ^{[1
]}

Akamatsu, Takuji ^{[1
]}

Uenoyama, Yoshito ^{[1
]}

Maeda, Chikara ^{[3
]}

Ono, Kazuo ^{[4
]}

Watanabe, Tomohiro ^{[2
]}

Yamashita, Yukitaka ^{[1
]}

机构：

[1] Japan Red Cross Wakayama Med Ctr, Dept Gastroenterol, Wakayama, Japan

[2] Kindai Univ Fac Med, Dept Gastroenterol & Hepatol, Osaka, Japan

[3] Japan Red Cross Wakayama Med Ctr, Dept Radiol, Wakayama, Japan

[4] Japan Red Cross Wakayama Med Ctr, Dept Pathol, Wakayama, Japan

来源：

INTERNAL MEDICINE | 2022年 / 61卷 / 22期

关键词：

hepatic neuroendocrine carcinoma; neuroendocrine neoplasm; thrombocytopenia; bone marrow metastasis; disseminated carcinomatosis of the bone marrow; PROGNOSTIC-FACTORS; CLINICOPATHOLOGICAL FEATURES; CLINICAL-FEATURES; LIVER; METASTASIS; NEOPLASMS; DIAGNOSIS; CANCER; BIOPSY; TUMORS;

D O I：

10.2169/internalmedicine.9465-22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An 82-year-old man with fever and back pain was referred to our hospital and was thus found to be thrombocytopenic. A bone marrow biopsy revealed the diffuse infiltration of poorly differentiated neuroendo-crine carcinoma (NEC). Computed tomography revealed a large hepatic mass. Considering the risk of bleed-ing due to thrombocytopenia, a needle biopsy was not performed. The patient rapidly deteriorated and died 10 days after presentation. An autopsy confirmed the diagnosis of primary hepatic NEC, with diffuse metas-tasis to the spleen, bone marrow, and systemic lymph nodes. This is an extremely rare case of NEC present-ing with thrombocytopenia due to extensive bone marrow and splenic infiltration.

引用

页码：3361 / 3368

页数：8

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