Magnetic targeting as a strategy to enhance therapeutic effects of mesenchymal stromal cells

被引:59
作者
Silva, Luisa H. A. [1 ]
Cruz, Fernanda F. [1 ]
Morales, Marcelo M. [2 ]
Weiss, Daniel J. [3 ]
Rocco, Patricia R. M. [1 ]
机构
[1] Univ Fed Rio de Janeiro, Lab Pulm Invest, Carlos Chagas Filho Inst Biophys, Av Carlos Chagas Filho 373, BR-21941902 Rio De Janeiro, RJ, Brazil
[2] Univ Fed Rio de Janeiro, Lab Cellular & Mol Physiol, Carlos Chagas Filho Inst Biophys, Av Carlos Chagas Filho 373, BR-21941902 Rio De Janeiro, RJ, Brazil
[3] Univ Vermont, Dept Med, Coll Med, Vermont Lung Ctr, 89 Beaumont Ave Given, Burlington, VT 05405 USA
关键词
Mesenchymal stromal cells; Superparamagnetic nanoparticles; Biocompatibility; Magnetic devices; Magnetic targeting; Cell therapy; IRON-OXIDE NANOPARTICLES; STEM-CELLS; DELIVERY-SYSTEM; VASCULAR INJURY; PARTICLES; REPAIR; MODEL; FIELD; PROLIFERATION; ACTIVATION;
D O I
10.1186/s13287-017-0523-4
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Mesenchymal stromal cells (MSCs) have been extensively investigated in the field of regenerative medicine. It is known that the success of MSC-based therapies depends primarily on effective cell delivery to the target site where they will secrete vesicles and soluble factors with immunomodulatory and potentially reparative properties. However, some lesions are located in sites that are difficult to access, such as the heart, spinal cord, and joints. Additionally, low MSC retention at target sites makes cell therapy short-lasting and, therefore, less effective. In this context, the magnetic targeting technique has emerged as a new strategy to aid delivery, increase retention, and enhance the effects of MSCs. This approach uses magnetic nanoparticles to magnetize MSCs and static magnetic fields to guide them in vivo, thus promoting more focused, effective, and lasting retention of MSCs at the target site. In the present review, we discuss the magnetic targeting technique, its principles, and the materials most commonly used; we also discuss its potential for MSC enhancement, and safety concerns that should be addressed before it can be applied in clinical practice.
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页数:8
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