Autologous skeletal myoblast sheet implantation for pediatric dilated cardiomyopathy: A case report

被引：6

作者：

Araki, Kanta ^{[1
]}

Taira, Masaki ^{[1
]}

Miyagawa, Shigeru ^{[1
]}

Kanaya, Tomomitsu ^{[1
]}

Okuda, Naoki ^{[1
]}

Toda, Koichi ^{[1
]}

Kuratani, Toru ^{[1
]}

Ueno, Takayoshi ^{[1
]}

Sawa, Yoshiki ^{[1
]}

机构：

[1] Osaka Univ, Dept Cardiovasc Surg, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

GENERAL THORACIC AND CARDIOVASCULAR SURGERY | 2021年 / 69卷 / 05期

关键词：

Autologous skeletal myoblast sheet; Cell therapy; Pediatric dilated cardiomyopathy; Myocardial regeneration; HEART-FAILURE;

D O I：

10.1007/s11748-020-01540-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background In children with dilated cardiomyopathy, heart transplantation is the last treatment option. However, new regenerative treatments, such as cell therapy, have attracted scientific attention. We have previously demonstrated the efficacy of autologous skeletal myoblast sheet implantation for treatment of ischemic and dilated cardiomyopathy in adults. Because of the mechanism underlying this cell therapy, a similar effectiveness is expected for patients with pediatric dilated cardiomyopathy. Case Herein, we describe the case of a child with dilated cardiomyopathy who underwent an autologous skeletal myoblast sheet implantation, which proved to be safe, and led to sustained maintenance and improvements in cardiac function and clinical status.

引用

页码：859 / 861

页数：3

共 7 条

[1] Longer preservation of cardiac performance by sheet-shaped myoblast implantation in dilated cardiomyopathic hamsters [J].

Kondoh, H ;

Sawa, Y ;

Miyagawa, S ;

Sakakida-Kitagawa, S ;

Memon, MA ;

Kawaguchi, N ;

Matsuura, N ;

Shimizu, T ;

Okano, T ;

Matsuda, H .

CARDIOVASCULAR RESEARCH, 2006, 69 (02) :466-475

[2] Phase I Clinical Trial of Autologous Stem Cell-Sheet Transplantation Therapy for Treating Cardiomyopathy [J].

Miyagawa, Shigeru ;

Domae, Keitaro ;

Yoshikawa, Yasushi ;

Fukushima, Satsuki ;

Nakamura, Teruya ;

Saito, Atsuhiro ;

Sakata, Yasushi ;

Hamada, Seiki ;

Toda, Koichi ;

Pak, Kyongsun ;

Takeuchi, Masahiro ;

Sawa, Yoshiki .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (04)

[3] Impaired Myocardium Regeneration With Skeletal Cell Sheets-A Preclinical Trial for Tissue-Engineered Regeneration Therapy [J].

Miyagawa, Shigeru ;

Saito, Atsuhiro ;

Sakaguchi, Taichi ;

Yoshikawa, Yasushi ;

Yamauchi, Takashi ;

Imanishi, Yukiko ;

Kawaguchi, Naomasa ;

Teramoto, Noboru ;

Matsuura, Nariaki ;

Iida, Hidehiro ;

Shimizu, Tatsuya ;

Okano, Teruo ;

Sawa, Yoshiki .

TRANSPLANTATION, 2010, 90 (04) :364-372

[4] Third Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report: Preimplant Characteristics and Outcomes [J].

Morales, David L. S. ;

Rossano, Joseph W. ;

VanderPluym, Christina ;

Lorts, Angela ;

Cantor, Ryan ;

St Louis, James D. ;

Koeh, Devin ;

Sutcliffe, David L. ;

Adachi, Iki ;

Kirklin, James K. ;

Rosenthal, David N. ;

Blume, Elizabeth D. .

ANNALS OF THORACIC SURGERY, 2019, 107 (04) :993-1004

[5] Sirtuin1 Regulates the Stem Cell Therapeutic Effects on Regenerative Capability for Treating Severe Heart Failure in a Juvenile Animal Model [J].

Ozawa, Hideto ;

Miyagawa, Shigeru ;

Fukushima, Satsuki ;

Itoh, Emiko ;

Harada, Akima ;

Saito, Atsuhiro ;

Ueno, Takayoshi ;

Toda, Koichi ;

Kuratani, Toru ;

Sawa, Yoshiki .

ANNALS OF THORACIC SURGERY, 2016, 102 (03) :803-812

[6]

Pavo IJ, 2017, WORLD J CARDIOL, V9, P147, DOI 10.4330/wjc.v9.i2.147

[7] Safety and Efficacy of Autologous Skeletal Myoblast Sheets (TCD-51073) for the Treatment of Severe Chronic Heart Failure Due to Ischemic Heart Disease [J].

Sawa, Yoshiki ;

Yoshikawa, Yasushi ;

Toda, Koichi ;

Fukushima, Satsuki ;

Yamazaki, Kenji ;

Ono, Minoru ;

Sakata, Yasushi ;

Hagiwara, Nobuhisa ;

Kinugawa, Koichiro ;

Miyagawa, Shigeru .

CIRCULATION JOURNAL, 2015, 79 (05) :991-+

← 1 →