Interleukin-17 inhibits Adult Hippocampal Neurogenesis

被引：70
作者：
Liu, Qiang [1 ,2 ]
Xin, Wei [1 ]
He, Ping [3 ]
Turner, Dharshaun [1 ]
Yin, Junxiang [1 ]
Gan, Yan [1 ]
Shi, Fu-Dong [1 ,2 ]
Wu, Jie [1 ,4 ]
机构：
[1] St Josephs Hosp, Barrow Neurol Inst, Div Neurol, Phoenix, AZ 85013 USA
[2] Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin 300052, Peoples R China
[3] Arizona State Univ, Dept Chem Engn, Tempe, AZ USA
[4] Shantou Univ, Coll Med, Dept Physiol, Shantou, Guangdong, Peoples R China
来源：
SCIENTIFIC REPORTS | 2014年 / 4卷
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
NATURAL-KILLER-CELLS; NEURAL STEM-CELLS; INDUCED DEGENERATION; INDUCED DEPRESSION; T-CELLS; BRAIN; IL-17; NEURONS; RECEPTOR; EXCITABILITY;
D O I：
10.1038/srep07554
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.
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页数：8
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