Sepsis: frontiers in supportive care, organisation and research

被引：70

作者：

Perner, Anders ^{[1
]}

Rhodes, Andrew ^{[2
]}

Venkatesh, Bala ^{[3
,4
,5
]}

Angus, Derek C. ^{[6
]}

Martin-Loeches, Ignacio ^{[7
,8
,9
]}

Preiser, Jean-Charles ^{[10
]}

Vincent, Jean-Louis ^{[10
]}

Marshall, John ^{[11
]}

Reinhart, Konrad ^{[12
]}

Joannidis, Michael ^{[13
]}

Opal, Steven M. ^{[14
]}

机构：

[1] Univ Copenhagen, Dept Intens Care Rigshosp, Copenhagen 1165, Denmark

[2] St Georges Univ London, St Georges Healthcare NHS Trust, London, England

[3] Univ Queensland, Wesley Hosp, Dept Intens Care, St Lucia, Qld, Australia

[4] Univ Queensland, Princess Alexandra Hosp, St Lucia, Qld, Australia

[5] Univ Sydney, Sydney, NSW, Australia

[6] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Pittsburgh, PA USA

[7] Multidisciplin Intens Care Res Organ MICRO, Wellcome Trust HRB Clin Res, Dublin, Ireland

[8] St James Univ Hosp, Trin Ctr Hlth Sci, Dept Clin Med, Dublin, Ireland

[9] CIBER Enfermedades Respirat CIBERES, Crit Care Ctr, Madrid, Spain

[10] Univ Iibre Bruxelles, Erasme Univ Hosp, Dept Intens Care, Brussels, Belgium

[11] Univ Toronto, St Michaels Hosp, Dept Surg & Crit Care Med, Toronto, ON, Canada

[12] Jena Univ Hosp, Jena, Germany

[13] Med Univ Innsbruck, Div Intens Care & Emergency Med, Innsbruck, Austria

[14] Brown Univ, Alpert Med Sch, Div Infect Dis, Providence, RI USA

来源：

INTENSIVE CARE MEDICINE | 2017年 / 43卷 / 04期

关键词：

Critical care medicine; Intensive care medicine; Sepsis; Shock; Renal failure; Acute respiratory failure; ACUTE KIDNEY INJURY; CRITICALLY-ILL PATIENTS; RESPIRATORY-DISTRESS-SYNDROME; CLINICAL-PRACTICE GUIDELINE; INTENSIVE INSULIN THERAPY; RENAL-REPLACEMENT THERAPY; LATE PARENTERAL-NUTRITION; ADJUSTED LIFE YEARS; SEPTIC SHOCK; MECHANICAL VENTILATION;

D O I：

10.1007/s00134-017-4677-4

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Because of its high incidence and clinical complexity, sepsis is a major challenge to clinicians and researchers and a global burden to healthcare systems and society. Despite recent progress, short-and long-term morbidity, mortality and costs remain high in both developed and developing countries. Thus, further improvements in supportive interventions and organisation of care are likely to have a substantial impact upon global health. In this narrative review, invited experts describe the challenges and progress to be made in sepsis research and care in the near future. We focus on supportive care (pulmonary, endocrine, renal, and nutritional support, mediator modulation and precision medicine), organisational themes (guidelines, outcome measures and stakeholder involvement) and clinical research as key areas to improving the care and outcomes of patients with sepsis.

引用

页码：496 / 508

页数：13

共 108 条

[1] Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome and Acute Lung Injury in Adults and Children: A Systematic Review with Meta-Analysis and Trial Sequential Analysis [J].

Afshari, Arash ;

Brok, Jesper ;

Moller, Ann M. ;

Wetterslev, Jorn .

ANESTHESIA AND ANALGESIA, 2011, 112 (06) :1411-1421

[2] Driving Pressure and Survival in the Acute Respiratory Distress Syndrome [J].

Amato, Marcelo B. P. ;

Meade, Maureen O. ;

Slutsky, Arthur S. ;

Brochard, Laurent ;

Costa, Eduardo L. V. ;

Schoenfeld, David A. ;

Stewart, Thomas E. ;

Briel, Matthias ;

Talmor, Daniel ;

Mercat, Alain ;

Richard, Jean-Christophe M. ;

Carvalho, Carlos R. R. ;

Brower, Roy G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (08) :747-755

[3] Effect of High-Dose Vitamin D3 on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency The VITdAL-ICU Randomized Clinical Trial [J].

Amrein, Karin ;

Schnedl, Christian ;

Holl, Alexander ;

Riedl, Regina ;

Christopher, Kenneth B. ;

Pachler, Christoph ;

Purkart, Tadeja Urbanic ;

Waltensdorfer, Andreas ;

Muench, Andreas ;

Warnkross, Helga ;

Stojakovic, Tatjana ;

Bisping, Egbert ;

Toller, Wolfgang ;

Smolle, Karl-Heinz ;

Berghold, Andrea ;

Pieber, Thomas R. ;

Dobnig, Harald .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 312 (15) :1520-1530

[4] Selenium in Intensive Care (SIC):: Results of a prospective. randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock [J].

Angstwurm, Matthias W. A. ;

Engelmann, Lothar ;

Zimmermann, Thomas ;

Lehmann, Christian ;

Spes, Christoph H. ;

Abel, Peter ;

Strauss, Richard ;

Meier-Hellmann, Andreas ;

Insel, Rudolf ;

Radke, Joachim ;

Schuettler, Juergen ;

Gaertner, Roland .

CRITICAL CARE MEDICINE, 2007, 35 (01) :118-126

[5] A systematic review and meta-analysis of early goal-directed therapy for septic shock: the ARISE, ProCESS and ProMISe Investigators [J].

Angus, D. C. ;

Barnato, A. E. ;

Bell, D. ;

Bellomo, R. ;

Chong, C. -R. ;

Coats, T. J. ;

Davies, A. ;

Delaney, A. ;

Harrison, D. A. ;

Holdgate, A. ;

Howe, B. ;

Huang, D. T. ;

Iwashyna, T. ;

Kellum, J. A. ;

Peake, S. L. ;

Pike, F. ;

Reade, M. C. ;

Rowan, K. M. ;

Singer, M. ;

Webb, S. A. R. ;

Weissfeld, L. A. ;

Yealy, D. M. ;

Young, J. D. .

INTENSIVE CARE MEDICINE, 2015, 41 (09) :1549-1560

[6] Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock [J].

Annane, D ;

Sébille, V ;

Charpentier, C ;

Bollaert, PE ;

François, B ;

Korach, JM ;

Capellier, G ;

Cohen, Y ;

Azoulay, E ;

Troché, G ;

Chaumet-Riffaut, P ;

Bellissant, E .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (07) :862-871

[7] Permissive Underfeeding or Standard Enteral Feeding in Critically Ill Adults [J].

Arabi, Yaseen M. ;

Aldawood, Abdulaziz S. ;

Haddad, Samir H. ;

Al-Dorzi, Hasan M. ;

Tamim, Hani M. ;

Jones, Gwynne ;

Mehta, Sangeeta ;

McIntyre, Lauralyn ;

Solaiman, Othman ;

Sakkijha, Maram H. ;

Sadat, Musharaf ;

Afesh, Lara .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (25) :2398-2408

[8] High versus Low Blood-Pressure Target in Patients with Septic Shock [J].

Asfar, Pierre ;

Meziani, Ferhat ;

Hamel, Jean-Francois ;

Grelon, Fabien ;

Megarbane, Bruno ;

Anguel, Nadia ;

Mira, Jean-Paul ;

Dequin, Pierre-Francois ;

Gergaud, Soizic ;

Weiss, Nicolas ;

Legay, Francois ;

Le Tulzo, Yves ;

Conrad, Marie ;

Robert, Rene ;

Gonzalez, Frederic ;

Guitton, Christophe ;

Tamion, Fabienne ;

Tonnelier, Jean-Marie ;

Guezennec, Pierre ;

Van der Linden, Thierry ;

Vieillard-Baron, Antoine ;

Mariotte, Eric ;

Pradel, Gael ;

Lesieur, Olivier ;

Ricard, Jean-Damien ;

Herve, Fabien ;

du Cheyron, Damien ;

Guerin, Claude ;

Mercat, Alain ;

Teboul, Jean-Louis ;

Radermacher, Peter .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (17) :1583-1593

[9] Septic acute kidney injury in critically ill patients: Clinical characteristics and outcomes [J].

Bagshaw, Sean M. ;

Uchino, Shigehiko ;

Bellomo, Rinaldo ;

Morimatsu, Hiroshi ;

Morgera, Stanislao ;

Schetz, Miet ;

Tan, Ian ;

Bouman, Catherine ;

Macedo, Ettiene ;

Gibney, Noel ;

Tolwani, Ashita ;

Oudemans-van Straaten, Heleen M. ;

Ronco, Claudio ;

Kellum, John A. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 2 (03) :431-439

[10] Asynchronies during mechanical ventilation are associated with mortality [J].

Blanch, Lluis ;

Villagra, Ana ;

Sales, Bernat ;

Montanya, Jaume ;

Lucangelo, Umberto ;

Lujan, Manel ;

Garcia-Esquirol, Oscar ;

Chacon, Encarna ;

Estruga, Anna ;

Oliva, Joan C. ;

Hernandez-Abadia, Alberto ;

Albaiceta, Guillermo M. ;

Fernandez-Mondejar, Enrique ;

Fernandez, Rafael ;

Lopez-Aguilar, Josefina ;

Villar, Jesus ;

Murias, Gaston ;

Kacmarek, Robert M. .

INTENSIVE CARE MEDICINE, 2015, 41 (04) :633-641

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