New cytotoxic withanolides from Physalis minima

被引：10
|
作者：
Zhang, Meng [1 ,2 ,3 ]
Jiang, Benke [2 ,3 ]
He, Xinya [2 ,3 ]
Cao, Shijie [2 ,3 ]
Ding, Liqin [2 ,3 ]
Kang, Ning [2 ,3 ]
Chen, Lixia [1 ]
Qiu, Feng [1 ,2 ,3 ]
机构：
[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Sch Tradit Chinese Mat Med, Wuya Coll Innovat,Minist Educ, Shenyang 110016, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China
[3] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, 10 Poyanghu Rd, Tianjin 301617, Peoples R China
来源：
FITOTERAPIA | 2020年 / 146卷
基金：
中国国家自然科学基金;
关键词：
Withanolides; Physalis minima; Physaminilides H-K; Cytotoxic activities; AERIAL PARTS; ANTIINFLAMMATORY WITHANOLIDES; TRYPANOCIDAL CONSTITUENTS; PLANTS; LEAVES;
D O I：
10.1016/j.fitote.2020.104728
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Phytochemical investigation of Physalis minima led to the isolation of six new withanolides, including physaminilides HeK (1-4), two artificial withanolides (5-6), and 19 known ones (7-25). Their structures were elucidated on the basis of spectroscopic analysis, including NMR and electronic circular dichroism (ECD) data. The isolates were evaluated for their cytotoxic activities against A375 human melanoma cells. Compounds 1, 8-9, 12-13, 15-17 and 19 exhibited significant cytotoxic activities with IC50 values in the range of 1.2-7.5 mu M.
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页数：6
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