Comparative subchronic studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in rats

被引:47
作者
Charles, JM
Cunny, HC
Wilson, RD
Bus, JS
机构
[1] DOW CHEM CO USA,MIDLAND,MI 48674
[2] CHARLES CONN & VAN GEMERT LLC,DURHAM,NC 27705
[3] RHONE POULENC AG CO,RES TRIANGLE PK,NC 27709
[4] JOHN WISE & ASSOCIATES LTD,LIBERTY,MO 64068
来源
FUNDAMENTAL AND APPLIED TOXICOLOGY | 1996年 / 33卷 / 02期
关键词
D O I
10.1006/faat.1996.0153
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Forms of 2,4-dichlorophenoxyacetic acid (collectively known as 2,4-D) are herbicides used to control a wide variety of broadleaf and woody plants. Subchronic toxicity studies in rats were conducted on three forms of 2,4-D: the parent form, 2,4-D acid; 2,4-D dimethylamine salt (DMA); and 2,4-D 2-ethylhexyl ester (2-EHE). Doses in the subchronic studies (on an acid equivalent basis) were 0, 1, 15, 100, and 300 mg/kg/day. Major treatment related findings in the three studies included decreases in red cell mass, decreases in T3 and T4 levels, decreases in ovary and testes weights, increases in liver, kidney, and thyroid weights, and cataracts and retinal degeneration (high-dose females). These data demonstrated the comparable toxicities of 2,4-D acid, DMA, and 2-EHE and support a subchronic no-observed-effect level of 15 mg/kg/day for all three forms. In summary, the findings of these studies indicate comparable low subchronic toxicity potentials among representative forms of 2,4-D. (C) 1996 Society of Toxicology
引用
收藏
页码:161 / 165
页数:5
相关论文
共 17 条
  • [1] BARTLETT M. S., 1937, J. Roy. Statist. Soc., (Suppl.), V4, P137
  • [2] Comparative subchronic and chronic dietary toxicity studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in the dog
    Charles, JM
    Dalgard, DW
    Cunny, HC
    Wilson, RD
    Bus, JS
    [J]. FUNDAMENTAL AND APPLIED TOXICOLOGY, 1996, 29 (01): : 78 - 85
  • [3] Chronic dietary toxicity/oncogenicity studies on 2,4-dichlorophenoxyacetic acid in rodents
    Charles, JM
    Bond, DM
    Jeffries, TK
    Yano, BL
    Stott, WT
    Johnson, KA
    Cunny, HC
    Wilson, RD
    Bus, JS
    [J]. FUNDAMENTAL AND APPLIED TOXICOLOGY, 1996, 33 (02): : 166 - 172
  • [4] TRANSFORMATIONS - SOME EXAMPLES REVISITED
    DRAPER, NR
    HUNTER, WG
    [J]. TECHNOMETRICS, 1969, 11 (01) : 23 - &
  • [6] NEW TABLES FOR MULTIPLE COMPARISONS WITH CONTROL
    DUNNETT, CW
    [J]. BIOMETRICS, 1964, 20 (03) : 482 - &
  • [7] *EPA, 1984, HAZ EV HUM DOM A 831
  • [8] *EPA, 1989, PEST FACT SHEET 2 4
  • [9] *EPA, 1984, HAZ EV HUM DOM A 821
  • [10] *EPA, 1984, HAZ EV HUM DOM A 832