Comparison of Adherence to Glimepiride/Metformin Sustained Release Once-daily Versus Glimepiride/Metformin Immediate Release BID Fixed-combination Therapy Using the Medication Event Monitoring System in Patients With Type 2 Diabetes

被引：5

作者：

Kim, Jong-Dai ^{[1
]}

Park, Cheol-Young ^{[2
]}

Cha, Bong-Yun ^{[3
]}

Ahn, Kyu Jeung ^{[4
]}

Kim, In Joo ^{[5
]}

Park, Kyong Soo ^{[6
]}

Lee, Hyung Woo ^{[7
]}

Min, Kyung-Wan ^{[8
]}

Won, Jong Chul ^{[9
]}

Chung, Min Young ^{[10
]}

Kim, Jae-Taek ^{[11
]}

Kang, Jun Goo ^{[12
]}

Park, Sung-Woo ^{[2
]}

机构：

[1] Konyang Univ, Konyang Univ Hosp, Dept Internal Med, Sch Med, Daejeon, South Korea

[2] Sungkyunkwan Univ, Kangbuk Samsung Med Ctr, Dept Internal Med, Sch Med, Seoul, South Korea

[3] Univ Catholic, Seoul St Marys Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

[4] Univ Kyunghee, Gangdong Kyunghee Univ Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

[5] Natl Univ Busan, Busan Natl Univ Hosp, Dept Internal Med, Sch Med, Busan, South Korea

[6] Natl Univ Seoul, Seoul Natl Univ Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

[7] Univ Yeungnam, Yeungnam Univ Hosp, Dept Internal Med, Sch Med, Daegu, South Korea

[8] Univ Eulji, Eulji Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

[9] Univ Baik, Sanggye Baik Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

[10] Natl Univ Chonnam, Chonnam Natl Univ Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

[11] Univ Chungang, Chungang Univ Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

[12] Univ Hallym, Pyungchon Sacred Heart Hosp, Dept Internal Med, Sch Med, Seoul, South Korea

来源：

CLINICAL THERAPEUTICS | 2018年 / 40卷 / 05期

关键词：

fixed dose combination; MEMS; sulfonylurea; glimepiride; ANTIRETROVIRAL THERAPY; REPORTED ADHERENCE; FREQUENCY; METFORMIN; ADULTS;

D O I：

10.1016/j.clinthera.2018.04.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: The purpose of this study was to compare the adherence of the glimepiride/metformin sustained release (GM-SR) once-daily fixed-dose combination and glimepiride/metformin immediate release (GM-IR) BID fixed-dose combination in type 2 diabetes therapies. Methods: An open-label, randomized, multicenter, parallel-group study was conducted at 11 hospitals in the Republic of Korea. A total of 168 patients with type 2 diabetes treated with > 4 mg of glimepiride and 1000 mg of metformin by using free or fixed-dose combination therapy for at least 2 weeks were enrolled. Patients were randomized to receive GM-SR 4/1000 mg once-daily or GM-IR 2/500 mg BID for 24 weeks. Adherence was compared by using the Medication Event Monitoring System (MEMS). Findings: A significant difference in adherence was observed between the 2 groups. Overall adherence, defined by the number of container openings divided by the number of prescribed doses, was 91.7% in the GM-SR group and 88.6% in the GM-IR group (P < 0.001). The percentage of treatment days with the correct number of doses taken was 85.3% in the GM-SR group and 75.1% in the GM-IR group (P < 0.001). The percentage of missed doses was 11.7% in the GM-SR group and 15.3% in the GM-IR group (P < 0.001). The percentage of doses taken in the correct time window and therapeutic coverage were higher in the GM-SR group (P < 0.001). There was no significant difference in glycosylated hemoglobin changes or number of adverse events between the 2 groups. A total of 168 patients randomized to receive GM-SR once daily (86 patients) or GM-IR twice daily (82 patients). Mean Age were 57.8 +/- 9.6 years old. Male : female ratio was 47.6 : 52.4 %. Body mass index were 66.3 +/- 12.0 kg/m2, Diabetes duration were 10.5 +/- 6.6 years. (C) 2018 Elsevier HS Journals, Inc. All rights reserved.

引用

页码：752 / 761

页数：10

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