Transcriptome Complexity in Cardiac Development and Diseases - An Expanding Universe Between Genome and Phenome

被引：5
作者：
Gao, Chen
Wang, Yibin
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Inst Mol Biol, Dept Anesthesiol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Inst Mol Biol, Dept Physiol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Inst Mol Biol, Dept Med, Los Angeles, CA 90095 USA
来源：
CIRCULATION JOURNAL | 2014年 / 78卷 / 05期
关键词：
Cardiovascular diseases; Genes; Molecular biology; Signal transduction; LONG NONCODING RNA; B MESSENGER-RNA; TRANSLATIONAL REPRESSOR NAT1; SPLICING REGULATION; WIDE IDENTIFICATION; MYOTONIC-DYSTROPHY; AID/APOBEC FAMILY; GENE-EXPRESSION; HUMAN HEART; TISSUE;
D O I：
10.1253/circj.CJ-14-0412
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.
引用
收藏
页码：1038 / 1047
页数：10
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