Microwave-Assisted Cobinamide Synthesis

被引：13

作者：

Proinsias, Keith O. ^{[1
]}

Karczewski, Maksymilian ^{[1
]}

Zieeniewska, Anna ^{[1
,2
]}

Gryko, Dorota ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

[2] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 16期

关键词：

VITAMIN-B12; CYANIDE; DERIVATIVES; COBALAMIN;

D O I：

10.1021/jo501364b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present a new method for the preparation of cobinamide (CN)(2)Cbi, a vitamin B-12 precursor, that should allow its broader utility. Treatment of vitamin B-12 with only NaCN and heating in a microwave reactor affords (CN)(2)Cbi as the sole product. The purification procedure was greatly simplified, allowing for easy isolation of the product in 94% yield. The use of microwave heating proved beneficial also for (CN)(2)Cbi(c-lactone) synthesis. Treatment of (CN)(2)Cbi with triethanolamine led to (CN)(2)Cbi(c-lactam).

引用

页码：7752 / 7757

页数：6

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