Proximal CD13 Versus Distal GATA-3 Expression in Renal Neoplasia According to WHO 2016 Classification

被引：5

作者：

Brunelli, Matteo ^{[1
]}

Erdini, Francesco ^{[1
]}

Cima, Luca ^{[1
]}

Eccher, Albino ^{[1
]}

Fioravanzo, Adele ^{[1
]}

Gobbo, Stefano ^{[1
]}

Segala, Diego ^{[1
]}

Ghimenton, Claudio ^{[1
]}

Mazzoleni, Guido ^{[2
]}

Munari, Enrico ^{[1
]}

Carella, Rodolfo ^{[2
]}

Martignoni, Guido ^{[1
,3
]}

机构：

[1] Univ Verona, Dept Diagnost & Publ Hlth, Ple LA Scuro 10, I-37134 Verona, Italy

[2] San Maurizio Hosp, Pathol Unit, Bolzano, Italy

[3] Pederzoli Hosp, Pathol Unit, Peschiera Del Garda, Italy

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2018年 / 26卷 / 05期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

CD13; CD10; renal cell carcinoma; WHO; 2016; clear cell papillary RCC; CELL CARCINOMA; IMMUNOHISTOCHEMICAL ANALYSIS; DIFFERENTIATION ANTIGENS; EPITHELIAL NEOPLASMS; DIAGNOSIS; MARKER; RCC; AMINOPEPTIDASES; ONCOCYTOMA; MICROARRAY;

D O I：

10.1097/PAI.0000000000000435

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Little is known about the aminopeptidase CD13 in renal neoplasia according to the new 2016 World Health Organization renal tumor classification. We selected 175 cases, including 79 clear cell, 31 papillary, 24 chromophobe, 8 clear cell papillary renal cell carcinomas (RCCs), 21 oncoytomas, and 12 microphthalmia transcription factor family translocation RCCs: 4 t(6;11)/transcription factor EB (TFEB), 7 t(Xp11) with 2 cystic variants and 1 t(X;17). GATA binding protein 3 (GATA-3) was inserted as control. Expression of proximal antigen CD13 was observed in 63/79 (80%) clear cell, 25/31 (81%) papillary, 3/8 (37%) clear cell papillary, 1/4 (25%) t(6;11)/TFEB, 2/7 (28%) cystic t(Xp11), and in 1/1 t(X;17) RCCs. All chromophobe RCC (0/24) and all oncocytomas (0/21) resulted negative. CD10 was seen in 76/79 (96%) clear cell, 15/31 (48%) papillary, 10/24 (42%) chromophobe, 1/8 (12%) clear cell papillary RCCs, 4/21 (19%) oncocytomas, 1/4 (25%) t(6;11)/TFEB, 2/7 (29%) cystic t(Xp11), and in 1/1 t(X;17) RCCs. GATA-3 was positive in 3/7 (42%) clear cell papillary RCCs and negative in all remaining RCCs, except a single chromophobe RCC and a single oncocytoma. We concluded that: (1) CD13 and GATA-3 immunostains may serve as a diagnostic aid in differentiating subtypes of RCC; (2) CD13 is always absent in chromophobe RCC and oncocytomas, whereas CD10 can be immunoexpressed in both; (3) CD13 should be included in a panel of antibodies to distinguish proximal renal tumors from distal renal tumors and between clear cell RCC versus microphthalmia transcription factor family translocations RCCs; and (4) when present, GATA-3 is specific for clear cell papillary RCC.

引用

页码：316 / 323

页数：8

共 35 条

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