Utility of positron emission tomography/computed tomography for nodal staging of cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia

被引：17
作者：
Tomaszewski, Jonathan M. [1 ]
Lau, Eddie [2 ,3 ]
Corry, June [1 ,3 ]
机构：
[1] Peter MacCallum Canc Ctr, Dept Radiat Oncol, Melbourne, Vic 8006, Australia
[2] Peter MacCallum Canc Ctr, Ctr Canc Imaging, Melbourne, Vic 8006, Australia
[3] Univ Melbourne, Melbourne, Vic 3010, Australia
来源：
AMERICAN JOURNAL OF OTOLARYNGOLOGY | 2014年 / 35卷 / 01期
关键词：
NECK-CANCER; HEAD; METASTASES; PET/CT;
D O I：
10.1016/j.amjoto.2013.08.014
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Purpose: Cutaneous squamous cell carcinoma (cSCC) behaves aggressively in patients with chronic lymphocytic leukemia (CLL). Lymphadenopathy due to CLL can obscure the clinical and radiological assessment of nodal involvement by cSCC. This study aimed to evaluate whether functional imaging with positron emission tomography (PET)/computed tomography (CT) may clarify the clinical picture. Methods: Five consecutive patients with cSCC and CLL who had a PET/CT scan for the purposes of cSCC staging between July 2000 and July 2010 were analyzed. PET/CT findings were compared to histopathology from subsequent neck dissection. Results: PET/CT can distinguish nodal cSCC from leukemic infiltration with high specificity, allowing prompt appropriate management of nodal disease. Conclusions: PET/CT is a promising modality for nodal staging in patients with cSCC and CLL, with the potential to improve outcomes in this poor prognosis group. Larger confirmatory studies are needed. Crown Copyright (C) 2014 Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：66 / 69
页数：4
相关论文
共 10 条
[1]   Primary care: Cutaneous squamous-cell carcinoma [J].
Alam, M ;
Ratner, D .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (13) :975-983
[2]  
Bin Cho S, 2005, DERMATOL SURG, V31, P442
[3]  
Brewer J.D., 2010, Expert Rev. Dermatol, V5, P525, DOI [10.1586/edm.10.48, DOI 10.1586/EDM.10.48]
[4]   Detection of lymph node metastases in head and neck cancer: A meta-analysis comparing US, USgFNAC, CT and MR imaging [J].
de Bondt, R. B. J. ;
Nelemans, P. J. ;
Hofman, P. A. M. ;
Casselman, J. W. ;
Kremer, B. ;
van Engelshoven, J. M. A. ;
Beets-Tan, R. G. H. .
EUROPEAN JOURNAL OF RADIOLOGY, 2007, 64 (02) :266-272
[5]   N1S3: A Revised Staging System for Head and Neck Cutaneous Squamous Cell Carcinoma With Lymph Node Metastases Results of 2 Australian Cancer Centers [J].
Forest, Veronique-Isabelle ;
Clark, Jonathan J. ;
Veness, Michael J. ;
Milross, Chris .
CANCER, 2010, 116 (05) :1298-1304
[6]  
Mak D, 2011, Q J NUCL MED MOL IM, V55, P487
[7]   Head and neck cancer:: Clinical usefulness and accuracy of PET/CT image fusion [J].
Schöder, H ;
Yeung, HWD ;
Gonen, M ;
Kraus, D ;
Larson, SM .
RADIOLOGY, 2004, 231 (01) :65-72
[8]   CERVICAL LYMPH-NODE METASTASIS - ASSESSMENT OF RADIOLOGIC CRITERIA [J].
VANDENBREKEL, MWM ;
STEL, HV ;
CASTELIJNS, JA ;
NAUTA, JJP ;
VANDERWAAL, I ;
VALK, J ;
MEYER, CJLM ;
SNOW, GB .
RADIOLOGY, 1990, 177 (02) :379-384
[9]   Defining patients with high-risk cutaneous squamous cell carcinoma [J].
Veness, Michael J. .
AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2006, 47 (01) :28-33
[10]   Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer [J].
Yamazaki, Yutaka ;
Saitoh, Masaaki ;
Notani, Ken-ichi ;
Tei, Kanchu ;
Totsuka, Yasunori ;
Takinami, Shu-Ichi ;
Kanegae, Kakuko ;
Inubushi, Masayuki ;
Tamaki, Nagara ;
Kitagawa, Yoshimasa .
ANNALS OF NUCLEAR MEDICINE, 2008, 22 (03) :177-184
1