Facile Access to 3,4-Disubstituted 2H-Chromenes via Domino [4+2] Annulation

被引：9
作者：
Prasad, Sure Siva [1 ,2 ]
Joshi, Dirgha Raj [1 ,2 ]
Kim, Ikyon [1 ,2 ]
机构：
[1] Yonsei Univ, Coll Pharm, 85 Songdogwahak Ro, Incheon 21983, South Korea
[2] Yonsei Univ, Yonsei Inst Pharmaceut Sci, 85 Songdogwahak Ro, Incheon 21983, South Korea
来源：
SYNTHESIS-STUTTGART | 2021年 / 53卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
chemical space; 2H-chromenes; domino reaction; intramolecular reaction; Horner-Wadsworth-Emmons olefination; one-pot three-component reaction; ORTHO-QUINONE METHIDES; ONE-POT; CHROMENES;
D O I：
10.1055/s-0040-1706089
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient synthetic route to polysubstituted 2H-chromenes was developed utilizing a domino O-alkylation/intramolecular Horner-Wadsworth-Emmons (HWE) olefination of diarylmethylphosphonates, which were readily accessed via Lewis acid mediated one-pot three-component coupling of aldehydes, phenols, and triethyl phosphite.
引用
收藏
页码：1503 / 1512
页数：10
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