Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

被引：3

作者：

Krishna, Singamsetty Radha ^{[1
]}

Rao, Mandava Venkata Naga Brahmeshwar ^{[1
]}

Raju, Tirmalaraju Satyanaryana ^{[1
]}

Himabindu, Vurimidi ^{[2
]}

Reddy, Ghanta Mahesh ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Res & Dev, Integrated Prod & Dev, Unit 3, Jinnaram 502325, Andhra Pradesh, India

[2] JNT Univ, Ctr Environm Sci, Inst Sci & Technol, Hyderabad 500072, Andhra Pradesh, India

来源：

E-JOURNAL OF CHEMISTRY | 2008年 / 5卷 / 03期

关键词：

Rosiglitazone; Drug; Impurities; Synthesis; HPLC and LC-MS;

D O I：

10.1155/2008/308724

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities.

引用

页码：562 / 566

页数：5