Efficient room-temperature synthesis of tri- and tetrasubstituted imidazoles catalyzed by ZrCl4

被引：173

作者：

Sharma, G. V. M. ^{[1
]}

Jyothi, Y. ^{[1
]}

Lakshmi, P. Sree ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Chem Div 3, Div Organ Chem 3, Discovery Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2006年 / 36卷 / 20期

关键词：

1,2-diarylethanedienones; imidazole glycoconjugates; three/four-component coupling reaction; tri/tetrasubstituted imidazoles;

D O I：

10.1080/00397910600773825

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general protocol has been developed for the rapid synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles in high yields using ZrCl4 as an efficient catalyst at room temperature. A variety of aromatic, aliphatic, and terpenoidal aldehydes underwent condensation with NH4OAc/amines to give the imidazoles. Similarly, the imidazole glycoconjugates are prepared in good yields from the corresponding glycosyl aldehydes.

引用

页码：2991 / 3000

页数：10

共 27 条

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