Clinical and biological implications of mutational spectrum in acute myeloid leukemia of FAB subtypes M4 and M5

被引：11

作者：

Cheng, Zhiheng ^{[1
]}

Hu, Kai ^{[2
,3
]}

Tian, Lei ^{[2
,3
]}

Dai, Yifeng ^{[4
,5
]}

Pang, Yifan

Cui, Wei ^{[6
]}

Zhao, Hongmian ^{[7
]}

Qin, Tong ^{[7
]}

Han, Yu ^{[7
]}

Hu, Ning ^{[7
]}

Chen, Li ^{[7
]}

Wang, Chao ^{[7
]}

Zhang, Yijie ^{[8
]}

Wu, Depei ^{[9
]}

Ke, Xiaoyan ^{[2
,3
]}

Shi, Jinlong ^{[1
,10
,11
]}

Fu, Lin ^{[2
,3
,7
]}

机构：

[1] Henan Univ, Huaihe Hosp, Translat Med Ctr, Kaifeng 475000, Peoples R China

[2] Peking Univ, Hosp 3, Dept Hematol, Beijing 100191, Peoples R China

[3] Peking Univ, Hosp 3, Lymphoma Res Ctr, Beijing 100191, Peoples R China

[4] Shantou Univ Med Coll, Lab Environm Med & Dev Toxicol, Shantou 515041, Peoples R China

[5] William Beaumont Hosp, Dept Med, Royal Oak, MI 48073 USA

[6] Peking Univ, Beijing Haidian Hosp, Hosp 3, Dept Clin Lab,Beijing Haidian Sect, Beijing 100080, Peoples R China

[7] Henan Univ, Huaihe Hosp, Dept Hematol, Kaifeng 475000, Peoples R China

[8] Henan Univ, Dept Resp, Huaihe Hosp, Kaifeng 475000, Peoples R China

[9] Soochow Univ, Affiliated Hosp 1, Dept Hematol, Suzhou 215006, Peoples R China

[10] Chinese Peoples Liberat Army Gen Hosp, Dept Biomed Engn, Beijing 100853, Peoples R China

[11] Chinese Peoples Liberat Army Gen Hosp, Dept Med Big Data, Beijing 100853, Peoples R China

来源：

CANCER GENE THERAPY | 2018年 / 25卷 / 3-4期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

CLASSIFICATION; PROGNOSIS;

D O I：

10.1038/s41417-018-0013-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mutational spectrum and molecular characteristics of acute myelomonocytic lineage leukemia, namely acute myeloid leukemia (AML) French-American-British (FAB) subtypes M4 and M5, are largely unknown. In order to explore the mutational spectrum and prognostic factors of FAB-M4 and -M5, next-generation sequencing (NGS) was performed to screen for mutated genes and fusion genes relevant to the pathogenesis of AML. Of the 63 patients enrolled in the study,

引用

页码：77 / 83

页数：7

共 19 条

[1] PROPOSAL FOR THE RECOGNITION OF MINIMALLY DIFFERENTIATED ACUTE MYELOID-LEUKEMIA (AML-MO) [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1991, 78 (03) :325-329

[2] Classification and Prognostic Evaluation of Myelodysplastic Syndromes [J].

Cazzola, Mario ;

Della Porta, Matteo G. ;

Travaglino, Erica ;

Malcovati, Luca .

SEMINARS IN ONCOLOGY, 2011, 38 (05) :627-634

[3] Acute Myeloid Leukemia [J].

Doehner, Hartmut ;

Weisdorf, Daniel J. ;

Bloomfield, Clara D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (12) :1136-1152

[4] Acute myeloid leukemia: 2013 update on risk-stratification and management [J].

Estey, Elihu H. .

AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (04) :317-327

[5] Mutations of myelodysplastic syndromes (MDS): An update [J].

Ganguly, Bani Bandana ;

Kadam, N. N. .

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2016, 769 :47-62

[6] Genomics-Driven Oncology: Framework for an Emerging Paradigm [J].

Garraway, Levi A. .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15) :1806-1814

[7] A novel hierarchical prognostic model of AML solely based on molecular mutations [J].

Grossmann, Vera ;

Schnittger, Susanne ;

Kohlmann, Alexander ;

Eder, Christiane ;

Roller, Andreas ;

Dicker, Frank ;

Schmid, Christoph ;

Wendtner, Clemens-Martin ;

Staib, Peter ;

Serve, Hubert ;

Kreuzer, Karl-Anton ;

Kern, Wolfgang ;

Haferlach, Torsten ;

Haferlach, Claudia .

BLOOD, 2012, 120 (15) :2963-2972

[8] Landscape of genetic lesions in 944 patients with myelodysplastic syndromes [J].

Haferlach, T. ;

Nagata, Y. ;

Grossmann, V. ;

Okuno, Y. ;

Bacher, U. ;

Nagae, G. ;

Schnittger, S. ;

Sanada, M. ;

Kon, A. ;

Alpermann, T. ;

Yoshida, K. ;

Roller, A. ;

Nadarajah, N. ;

Shiraishi, Y. ;

Shiozawa, Y. ;

Chiba, K. ;

Tanaka, H. ;

Koeffler, H. P. ;

Klein, H-U ;

Dugas, M. ;

Aburatani, H. ;

Kohlmann, A. ;

Miyano, S. ;

Haferlach, C. ;

Kern, W. ;

Ogawa, S. .

LEUKEMIA, 2014, 28 (02) :241-247

[9] Next-generation sequencing - feasibility and practicality in haematology [J].

Kohlmann, Alexander ;

Grossmann, Vera ;

Nadarajah, Niroshan ;

Haferlach, Torsten .

BRITISH JOURNAL OF HAEMATOLOGY, 2013, 160 (06) :736-753

[10] Prognosis of patients with core binding factor acute myeloid leukemia after first relapse [J].

Kurosawa, Saiko ;

Miyawaki, Shuichi ;

Yamaguchi, Takuhiro ;

Kanamori, Heiwa ;

Sakura, Toru ;

Moriuchi, Yukiyoshi ;

Sano, Fumiaki ;

Kobayashi, Takeshi ;

Yasumoto, Atsushi ;

Hatanaka, Kazuo ;

Yanada, Masamitsu ;

Nawa, Yuichiro ;

Takeuchi, Jin ;

Nakamura, Yukinori ;

Fujisawa, Shin ;

Shibayama, Hirohiko ;

Miura, Ikuo ;

Fukuda, Takahiro .

HAEMATOLOGICA, 2013, 98 (10) :1525-1531

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