A review on flavonoid-based scaffolds as multi-target-directed ligands (MTDLs) for Alzheimer's disease

被引：96
作者：
Jalili-Baleh, Leili [1 ]
Babaei, Elaheh [2 ]
Abdpour, Shahin [3 ]
Bukhari, Syed Nasir Abbas [4 ]
Foroumadi, Alireza [1 ,5 ]
Ramazani, Ali [3 ]
Sharifzadeh, Mohammad [6 ]
Abdollahi, Mohammad [1 ]
Khoobi, Mehdi [1 ,7 ]
机构：
[1] Univ Tehran Med Sci, TIPS, Tehran 1417614411, Iran
[2] Yazd Univ, Dept Chem, Fac Sci, Yazd, Iran
[3] Univ Zanjan, Dept Chem, Zanjan, Iran
[4] Jouf Univ, Dept Pharmaceut Chem, Coll Pharm, Aljouf 2014, Sakaka, Saudi Arabia
[5] Univ Tehran Med Sci, Dept Med Chem, Fac Pharm, Tehran, Iran
[6] Univ Tehran Med Sci, Dept Pharmacol & Toxicol, Toxicol & Poisoning Res Ctr, Fac Pharm, Tehran, Iran
[7] Univ Tehran Med Sci, Dept Pharmaceut Biomat, Fac Pharm, Tehran, Iran
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2018年 / 152卷
关键词：
Chromanone; Multi-target drug ligands (MTDLs); Cholinesterase; Beta-secretase; Monoamine oxidase; Amyloid-beta; MONOAMINE-OXIDASE-B; BETA-SECRETASE BACE-1; ACETYLCHOLINESTERASE INHIBITORS; MULTIFUNCTIONAL AGENTS; FIBRIL FORMATION; CHROMONE DERIVATIVES; MOUSE MODEL; IN-VITRO; ANTICHOLINESTERASE ACTIVITY; PHARMACOLOGICAL EVALUATION;
D O I：
10.1016/j.ejmech.2018.05.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Alzheimer's disease (AD), the most common form of dementia, is a multifactorial neurodegenerative disease. The target enzymes inhibition including cholinesterase, beta-secretase, monoamine oxidase and inhibition of amyloid-beta aggregation as well as oxidative stress and metal chelation play an important role in the pathogenesis of AD. Chroman-4-one scaffold with benzo-gamma-pyrone network is a privileged structure in organic synthesis and drug design. A large number of research has been carried out on modified naturally occurring chromanone scaffolds and/or synthesized new analogues, to obtain effective drugs for AD management. The present review summarizes aspects related to the multi-target directed ligands (MTDLs) strategy in enzyme targets modulation performed with natural and synthesized chroman-4-one-based structures to look at their potential in the management of multifactorial Alzheimer's disease. (C) 2018 Elsevier Masson SAS. All rights reserved.
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收藏
页码：570 / 589
页数：20
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