Engineering mechanical microenvironment of macrophage and its biomedical applications

被引：24

作者：

Li, Jing ^{[1
,2
,3
,6
,7
]}

Li, Yuhui ^{[3
,4
]}

Gao, Bin ^{[3
,4
,5
]}

Qin, Chuanguang ^{[6
,7
]}

He, Yining ^{[8
]}

Xu, Feng ^{[3
,4
]}

Yang, Hui ^{[1
,2
]}

Lin, Min ^{[3
,4
]}

机构：

[1] Northwestern Polytech Univ, Sch Life Sci, Xian 710072, Shaanxi, Peoples R China

[2] Northwestern Polytech Univ, Res Ctr Special Environm Biomech & Med Engn, Xian 710072, Shaanxi, Peoples R China

[3] Xi An Jiao Tong Univ, BEBC, Xian 710049, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Key Lib Biomed Informat Engn, Minist Educ, Xian 710049, Shaanxi, Peoples R China

[5] Fourth Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian 710032, Shaanxi, Peoples R China

[6] Northwestern Polytech Univ, Minist Educ, Key Lab Space Phys & Chem, Xian 710072, Shaanxi, Peoples R China

[7] Northwestern Polytech Univ, Key Lab Macromol Sci & Technol Shanxi Prov, Dept Appl Chem, Sch Sci, Xian 710072, Shaanxi, Peoples R China

[8] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China

来源：

NANOMEDICINE | 2018年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

biomedical application; macrophages; mechanical environment; stiffness; stress/strain; EXTRACELLULAR-MATRIX; ALVEOLAR MACROPHAGES; GENE-EXPRESSION; CELL MECHANICS; SHEAR-STRESS; IN-VIVO; TUMOR-MICROENVIRONMENT; INSULIN-RESISTANCE; DENDRITIC CELLS; ACTIVATION;

D O I：

10.2217/nnm-2017-0324

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Macrophages are the most plastic cells in the hematopoietic system and can be widely found in almost all tissues. Recently studies have shown that mechanical cues (e.g., matrix stiffness and stress/strain) can significantly affect macrophage behaviors. Although existing reviews on the physical and mechanical cues that regulate the macrophage's phenotype are available, engineering mechanical microenvironment of macrophages in vitro as well as a comprehensive overview and prospects for their biomedical applications (e.g., tissue engineering and immunotherapy) has yet to be summarized. Thus, this review provides an overview on the existing methods for engineering mechanical microenvironment of macrophages in vitro and then a section on their biomedical applications and further perspectives are presented.

引用

页码：555 / 576

页数：22

共 152 条

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