CU2O-Catalyzed C(SP3)-H/C(SP3)-H Cross-Coupling Using TEMPO: Synthesis of 3-(2-Oxoalkyl)-3-hydroxyoxindoles

被引：9

作者：

Wang, Baoshuang ^{[1
]}

Zhu, Jiayi ^{[1
]}

Wei, Yang ^{[1
]}

Luo, Guotian ^{[1
]}

Qu, Hongen ^{[1
]}

Liu, Liang-Xian ^{[1
]}

机构：

[1] Gannan Normal Univ, Key Lab, Coll Chem & Chem Engn, Jiangxi Univ Funct Mat Chem, Ganzhou 341000, Jiangxi, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 24期

关键词：

Cross-coupling; 3-hydroxyindole; methyl ketone; TEMPO; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; DECARBOXYLATIVE ADDITION; ACTIVATED ALKENES; MOLECULAR-OXYGEN; OXINDOLES; OXIDATIONS; 3-HYDROXY-2-OXINDOLES; HYDROXYLATION; DERIVATIVES;

D O I：

10.1080/00397911.2015.1111383

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, convenient, and efficient oxidative cross-coupling reaction of oxindoles with ketones toward a variety of 3-(2-oxoalkyl)-3-hydroxyoxindoles in moderate to excellent yields has been developed. This transformation proceeds via a tandem oxidative cross-coupling by using 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) in air as an environmentally benign oxidant. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C3 position of oxindoles.

引用

页码：2841 / 2848

页数：8

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