Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

被引：261
作者：
Patterson, Stephen [1 ]
Wyllie, Susan [2 ]
机构：
[1] Univ Dundee, Sir James Black Ctr, Coll Life Sci, Div Biol Chem & Drug Discovery, Dundee, Scotland
[2] Univ Dundee, Wellcome Trust Bioctr, Coll Life Sci, Div Biol Chem & Drug Discovery, Dundee, Scotland
来源：
TRENDS IN PARASITOLOGY | 2014年 / 30卷 / 06期
基金：
英国惠康基金;
关键词：
trypanosomatids; nitroaromatics; nitroreductase; pro-drugs; bioactivation; HUMAN AFRICAN TRYPANOSOMIASIS; GAMBIENSE SLEEPING SICKNESS; MYCOBACTERIUM-TUBERCULOSIS; VISCERAL LEISHMANIASIS; TRYPANOCIDAL ACTIVITY; CROSS-RESISTANCE; CHAGAS-DISEASE; BENZNIDAZOLE; NIFURTIMOX; NITROIMIDAZOLE;
D O I：
10.1016/j.pt.2014.04.003
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
There is an urgent need for new, safer, and effective treatments for the diseases caused by the protozoan parasites Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. In the search for more effective drugs to treat these 'neglected diseases' researchers have chosen to reassess the therapeutic value of nitroaromatic compounds. Previously avoided in drug discovery programs owing to potential toxicity issues, a nitro drug is now being used successfully as part of a combination therapy for human African trypanosomiasis. We describe here the rehabilitation of nitro drugs for the treatment of trypanosomatid diseases and discuss the future prospects for this compound class.
引用
收藏
页码：289 / 298
页数：10
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