Purpose: Using specialized tools, we assessed patients receiving perampanel (PER) to investigate its effects on aggression and depression, as well as the impact of other concomitant antiepileptic drugs (AEDs) on those conditions. Method: Seventy-seven patients with epilepsy were initially enrolled, then examined at entry and 12 weeks later (endpoint). At both examinations, assessments were performed with the Buss Perry Aggression Questionnaire (BAQ) and Neurological Disorders Depression Inventory for Epilepsy (NDDI-E). Ultimately, 59 patients completed the study. Results: Total BAQ (p = 0.013) and NDDI-E (p = 0.000) scores at the endpoint were significantly increased in comparison with those at entry. Analysis with 4 subscales showed increases in both verbal and physical aggression, while multivariate analysis revealed that concomitant AED administration did not have a significant impact on the increase of BAQ or NDDI-E score. A dose-dependent effect of PER was confirmed in BAQ, but not NDDI-E results. PER was discontinued due to adverse psychiatric effects in 3.9% of the patients. Conclusions: The present findings indicate that PER increases assessment scores indicative of aggression as well as depression. No additional aggression-augmenting effect was seen with concomitant AED administration.
机构:
Banner Univ, Med Ctr, Phoenix, AZ 85006 USA
Banner Univ, Neurosci Inst, 1012 East Willetta St,2nd Floor,Suite 54, Phoenix, AZ 85006 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Chung, Steve
;
Williams, Betsy
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Inc, Eisai Med & Sci Affairs, 100 Tice Blvd, Woodcliff Lake, NJ 07677 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Williams, Betsy
;
Dobrinsky, Cindy
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Inc, Eisai Med & Sci Affairs, 100 Tice Blvd, Woodcliff Lake, NJ 07677 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Dobrinsky, Cindy
;
Patten, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Ltd, European Knowledge Ctr, Mosquito Way, Hatfield AL10 9SN, Herts, EnglandBanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Patten, Anna
;
Yang, Haichen
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Inc, Eisai Neurosci Prod Creat Unit, 155 Tice Blvd, Woodcliff Lake, NJ 07677 USA
Eisai Neurosci Prod Creat Unit, 1012 East Willetta St, Woodcliff Lake, NJ 07677 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Yang, Haichen
;
Laurenza, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Inc, Eisai Neurol Business Grp, 155 Tice Blvd, Woodcliff Lake, NJ 07677 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
机构:
NYU Comprehens Epilepsy Ctr, New York, NY 10016 USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
French, Jacqueline A.
;
Krauss, Gregory L.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ Hosp, Baltimore, MD 21287 USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Krauss, Gregory L.
;
Wechsler, Robert T.
论文数: 0引用数: 0
h-index: 0
机构:
Idaho Comprehens Epilepsy Ctr, Boise, ID USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Wechsler, Robert T.
;
Wang, Xue-Feng
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R ChinaNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Wang, Xue-Feng
;
DiVentura, Bree
论文数: 0引用数: 0
h-index: 0
机构:
Epilepsy Study Consortium, Herndon, VA USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
DiVentura, Bree
;
Brandt, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Bethel Epilepsy Ctr, Bielefeld, GermanyNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Brandt, Christian
;
Trinka, Eugen
论文数: 0引用数: 0
h-index: 0
机构:
Paracelsus Med Univ, CDK, Dept Neurol, Salzburg, Austria
Ctr Cognit Neurosci, Salzburg, AustriaNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Trinka, Eugen
;
O'Brien, Terence J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3010, Australia
Univ Melbourne, Royal Melbourne Hosp, Dept Neurol, Melbourne, Vic 3010, AustraliaNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
O'Brien, Terence J.
;
Laurenza, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Neurosci Prod Creat Unit, Woodcliff Lake, NJ USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Laurenza, Antonio
;
Patten, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Eisai, Dept Biostat, Hatfield, Herts, EnglandNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Patten, Anna
;
Bibbiani, Francesco
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Neurosci Prod Creat Unit, Woodcliff Lake, NJ USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
机构:
Banner Univ, Med Ctr, Phoenix, AZ 85006 USA
Banner Univ, Neurosci Inst, 1012 East Willetta St,2nd Floor,Suite 54, Phoenix, AZ 85006 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Chung, Steve
;
Williams, Betsy
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Inc, Eisai Med & Sci Affairs, 100 Tice Blvd, Woodcliff Lake, NJ 07677 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Williams, Betsy
;
Dobrinsky, Cindy
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Inc, Eisai Med & Sci Affairs, 100 Tice Blvd, Woodcliff Lake, NJ 07677 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Dobrinsky, Cindy
;
Patten, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Ltd, European Knowledge Ctr, Mosquito Way, Hatfield AL10 9SN, Herts, EnglandBanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Patten, Anna
;
Yang, Haichen
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Inc, Eisai Neurosci Prod Creat Unit, 155 Tice Blvd, Woodcliff Lake, NJ 07677 USA
Eisai Neurosci Prod Creat Unit, 1012 East Willetta St, Woodcliff Lake, NJ 07677 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
Yang, Haichen
;
Laurenza, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Inc, Eisai Neurol Business Grp, 155 Tice Blvd, Woodcliff Lake, NJ 07677 USABanner Univ, Med Ctr, Phoenix, AZ 85006 USA
机构:
NYU Comprehens Epilepsy Ctr, New York, NY 10016 USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
French, Jacqueline A.
;
Krauss, Gregory L.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ Hosp, Baltimore, MD 21287 USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Krauss, Gregory L.
;
Wechsler, Robert T.
论文数: 0引用数: 0
h-index: 0
机构:
Idaho Comprehens Epilepsy Ctr, Boise, ID USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Wechsler, Robert T.
;
Wang, Xue-Feng
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R ChinaNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Wang, Xue-Feng
;
DiVentura, Bree
论文数: 0引用数: 0
h-index: 0
机构:
Epilepsy Study Consortium, Herndon, VA USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
DiVentura, Bree
;
Brandt, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Bethel Epilepsy Ctr, Bielefeld, GermanyNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Brandt, Christian
;
Trinka, Eugen
论文数: 0引用数: 0
h-index: 0
机构:
Paracelsus Med Univ, CDK, Dept Neurol, Salzburg, Austria
Ctr Cognit Neurosci, Salzburg, AustriaNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Trinka, Eugen
;
O'Brien, Terence J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3010, Australia
Univ Melbourne, Royal Melbourne Hosp, Dept Neurol, Melbourne, Vic 3010, AustraliaNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
O'Brien, Terence J.
;
Laurenza, Antonio
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Neurosci Prod Creat Unit, Woodcliff Lake, NJ USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Laurenza, Antonio
;
Patten, Anna
论文数: 0引用数: 0
h-index: 0
机构:
Eisai, Dept Biostat, Hatfield, Herts, EnglandNYU Comprehens Epilepsy Ctr, New York, NY 10016 USA
Patten, Anna
;
Bibbiani, Francesco
论文数: 0引用数: 0
h-index: 0
机构:
Eisai Neurosci Prod Creat Unit, Woodcliff Lake, NJ USANYU Comprehens Epilepsy Ctr, New York, NY 10016 USA