Targeting epigenome with dietary nutrients in cancer: Current advances and future challenges

被引：20

作者：

Khan, Mohammad Imran ^{[1
,2
]}

Rath, Suvasmita ^{[1
]}

Adhami, Vaciar Mustafa ^{[1
]}

Mukhtar, Hasan ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Dermatol, 1300 Univ Ave MSC 4385, Madison, WI 53706 USA

[2] King Abdulaziz Univ, Dept Biochem, Fac Sci, Jeddah, Saudi Arabia

来源：

PHARMACOLOGICAL RESEARCH | 2018年 / 129卷

关键词：

Methylation; Acetylation; Histones; miRNAs; IncRNAs; Polyphenols; Epigenome; Natural products; TUMOR-SUPPRESSOR GENES; LONG NONCODING RNAS; DNA METHYLATION PATTERNS; HISTONE LYSINE DEMETHYLASES; TO-MESENCHYMAL TRANSITION; CURCUMIN INHIBITS GROWTH; PROSTATE-CANCER; PANCREATIC-CANCER; HUMAN BREAST; CELL-GROWTH;

D O I：

10.1016/j.phrs.2017.12.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tumorigenesis and epigenetic are closely linked with each other. Epigenetic changes are potential regulators of gene expression without involving any change in the DNA itself. More interestingly, epigenetic changes are reversible heritable changes which pass through generations. Many dietary bioactive ingredients regulate epigenetic control of cells and influence biochemical processes. Correlation between epigenetic regulation and cancer onset has been well established. Recent studies provide important information on the role of bioactive dietary components in cancer prevention and therapy. Several bioactive components are responsible for modification of the epigenome by affecting DNA methylation, histone modification, micro RNAs (miRNAs) and long non-coding RNAs (IncRNAs). This review summarizes recent advancements in this field and describes the role of many bioactive components in regulating human epigenome and how these modifications can be exploited for prevention and treatment of cancer. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：375 / 387

页数：13

共 198 条

[1] RETRACTED: Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF (Retracted article. See vol. 78, pg. 5466, 2018) [J].

Ali, Shadan ;

Ahmad, Aamir ;

Banerjee, Sanjeev ;

Padhye, Subhash ;

Dominiak, Kristin ;

Schaffert, Jacqueline M. ;

Wang, Zhiwei ;

Philip, Philip A. ;

Sarkar, Fazlul H. .

CANCER RESEARCH, 2010, 70 (09) :3606-3617

[2]

[Anonymous], CRIT REV FOOD SCI NU, DOI DOI 10.1080/10408398.2015.1062353

[3]

[Anonymous], EVID BASED COMPLEMEN

[4]

[Anonymous], EVID BASED COMPLEMEN

[5] Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition [J].

Appari, Mahesh ;

Babu, Kamesh R. ;

Kaczorowski, Adam ;

Gross, Wolfgang ;

Herr, Ingrid .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 45 (04) :1391-1400

[6] Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A [J].

Arab, Khelifa ;

Park, Yoon Jung ;

Lindroth, Anders M. ;

Schaefer, Andrea ;

Oakes, Christopher ;

Weichenhan, Dieter ;

Lukanova, Annekatrin ;

Lundin, Eva ;

Risch, Angela ;

Meister, Michael ;

Dienemann, Hendrik ;

Dyckhoff, Gerhard ;

Herold-Mende, Christel ;

Grummt, Ingrid ;

Niehrs, Christof ;

Plass, Christoph .

MOLECULAR CELL, 2014, 55 (04) :604-614

[7] Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms [J].

Athar, Mohammad ;

Back, Jung Ho ;

Kopelovich, Levy ;

Bickers, David R. ;

Kim, Arianna L. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2009, 486 (02) :95-102

[8] Genistein-induced mir-23b expression inhibits the growth of breast cancer cells [J].

Avci, Cigir Biray ;

Susluer, Sunde Yilmaz ;

Caglar, Hasan Onur ;

Balci, Tugce ;

Aygunes, Duygu ;

Dodurga, Yavuz ;

Gunduz, Cumhur .

WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY, 2015, 19 (01) :32-35

[9]

Azimi Ako, 2015, Asian Pac J Cancer Prev, V16, P6463

[10] Novel ultrasound-responsive chitosan/perfluorohexane nanodroplets for image-guided smart delivery of an anticancer agent: Curcumin [J].

Baghbani, Fatemeh ;

Chegeni, Mahdieh ;

Mortarzadeh, Fathollah ;

Hadian-Ghazvini, Samaneh ;

Raz, Majid .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 74 :186-193

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