Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies

被引：14
作者：
Tschida, Barbara R. [1 ,2 ,3 ]
Largaespada, David A. [1 ,2 ,3 ]
Keng, Vincent W. [4 ]
机构：
[1] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Ctr Genome Engn, Minneapolis, MN 55455 USA
[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2014年 / 27卷
关键词：
Transposable elements; Sleeping Beauty; Insertional mutagenesis; Mouse models; Cancer gene discovery; INTEGRATED GENOMIC ANALYSIS; HEPATOCELLULAR-CARCINOMA; SOMATIC MUTAGENESIS; COLORECTAL-CANCER; MICE; REVEALS; CELL; MUTATIONS; PATHWAYS; TUMORS;
D O I：
10.1016/j.semcdb.2014.01.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The genetic complexity and heterogeneity of cancer has posed a problem in designing rationally targeted therapies effective in a large proportion of human cancer. Genomic characterization of many cancer types has provided a staggering amount of data that needs to be interpreted to further our understanding of this disease. Forward genetic screening in mice using Sleeping Beauty (SB) based insertional mutagenesis is an effective method for candidate cancer gene discovery that can aid in distinguishing driver from passenger mutations in human cancer. This system has been adapted for unbiased screens to identify drivers of multiple cancer types. These screens have already identified hundreds of candidate cancer-promoting mutations. These can be used to develop new mouse models for further study, which may prove useful for therapeutic testing. SB technology may also hold the key for rapid generation of reverse genetic mouse models of cancer, and has already been used to model glioblastoma and liver cancer. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：86 / 95
页数：10
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