Cdc42 regulates cranial suture morphogenesis and ossification

被引：9

作者：

Aizawa, Ryo ^{[1
,2
]}

Yamada, Atsushi ^{[1
]}

Seki, Tatsuaki ^{[2
]}

Tanaka, Junichi ^{[3
]}

Nagahama, Ryo ^{[1
,4
]}

Ikehata, Mikiko ^{[1
,5
]}

Kato, Tadashi ^{[1
,6
]}

Sakashita, Akiko ^{[6
]}

Ogata, Hiroaki ^{[6
]}

Chikazu, Daichi ^{[5
]}

Maki, Koutaro ^{[4
]}

Mishima, Kenji ^{[3
]}

Yamamoto, Matsuo ^{[2
]}

Kamijo, Ryutaro ^{[1
]}

机构：

[1] Showa Univ, Sch Dent, Dept Biochem, Shinagawa, Tokyo, Japan

[2] Showa Univ, Sch Dent, Dept Periodontol, Ohta, Gunma, Japan

[3] Showa Univ, Sch Dent, Dept Oral Diagnost Sci, Div Pathol, Shinagawa, Tokyo, Japan

[4] Showa Univ, Sch Dent, Dept Orthodont, Ohta, Tokyo, Japan

[5] Tokyo Med Univ, Dept Oral & Maxillofacial Surg, Tokyo, Japan

[6] Showa Univ, Northern Yokohama Hosp, Dept Internal Med, Yokohama, Kanagawa, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2019年 / 512卷 / 02期

基金：

日本学术振兴会;

关键词：

Cdc42; Conditional knockout mice; Suture; Osteogenesis; NEURAL CREST; CARTILAGE DEVELOPMENT; INDIAN HEDGEHOG; FRACTURE REPAIR; MUTATIONS; TWIST; BONE; GENE; EXPRESSION; CELLS;

D O I：

10.1016/j.bbrc.2019.02.106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cdc42 (cell division cycle 42) is ubiquitously expressed small GTPases belonging to the Rho family of proteins. Previously, we generated limb bud mesenchyme-specific Cdc42 inactivated mice (Cdc42 conditional knockout mice; Cdc42(fl/fl); Prx1-Cre), which showed short limbs and cranial bone deformities, though the mechanism related to the cranium phenotype was unclear. In the present study, we investigated the role of Cdc42 in cranial bone development. Our results showed that loss of Cdc42 caused a defect of intramembranous ossification in cranial bone tissues which is related to decreased expressions of cranial suture morphogenesis genes, including Indian hedgehog (Ihh) and bone morphogenetic proteins (BMPs). These findings demonstrate that Cdc42 plays a crucial role in cranial osteogenesis, and is controlled by Ihh- and BMP-mediated signaling during cranium development. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：145 / 149

页数：5

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