Neuroendocrine regulatory peptide-1 and-2: Novel bioactive peptides processed from VGF

被引：23
作者：
Toshinai, K. [1 ]
Nakazato, M. [1 ]
机构：
[1] Miyazaki Univ, Fac Med, Div Internal Med, Miyazaki 8891692, Japan
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 11-12期
关键词：
Neuroendocrine regulatory peptide; vasopressin; hypothalamus; VGF; processing; feeding regulation; PROTEIN-COUPLED RECEPTORS; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA; FEEDING-BEHAVIOR; ANGIOTENSIN-II; GROWTH-FACTOR; ENCODING VGF; GENE; RAT; NEUROPEPTIDE;
D O I：
10.1007/s00018-009-8796-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuroendocrine regulatory peptides (NERP)-1 and NERP-2 are derived from distinct regions of VGF, a neurosecretory protein that was originally identified as a product of a nerve growth factor-responsive gene in rat PC12 cells. The amino acid length of human NERP-1 is 26, and that of rat NERP-1 is 25. Human and rat NERP-2 are both 38 amino acid peptides. NERPs colocalize with vasopressin in the storage granules of the paraventricular and supraoptic nuclei in the hypothalamus of both rats and humans. Administration of NERPs suppresses hypertonic saline- or angiotensin II-induced vasopressin release from the hypothalamus and pituitary. Thus, VGF is a precursor of multiple bioactive peptides with diverse neuroendocrine functions, and NERPs are novel hypothalamic peptides involved in the control of body fluid homeostasis by regulating vasopressin release.
引用
收藏
页码：1939 / 1945
页数：7
相关论文
共 50 条
[41]   Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 [J].
Tanaka, H ;
Yoshida, T ;
Miyamoto, N ;
Motoike, T ;
Kurosu, H ;
Shibata, K ;
Yamanaka, A ;
Williams, SC ;
Richardson, JA ;
Tsujino, N ;
Garry, MG ;
Lerner, MR ;
King, DS ;
O'Dowd, BF ;
Sakurai, T ;
Yanagisawa, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :6251-6256
[42]   Mechanisms of disease - The chromogranin-secretogranin family. [J].
Taupenot, L ;
Harper, KL ;
O'Connor, DT .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1134-1149
[43]   The neuropeptide VGF produces antidepressant-like Behavioral effects and enhances proliferation in the hippocampus [J].
Thakker-Varia, Smita ;
Krol, Jennifer Jernstedt ;
Nettleton, Jacob ;
Bilimoria, Parizad M. ;
Bangasser, Debra A. ;
Shors, Tracey J. ;
Black, Ira B. ;
Alder, Janet .
JOURNAL OF NEUROSCIENCE, 2007, 27 (45) :12156-12167
[44]   Isolation and characterization of VGF peptides in rat brain.: Role of PC1/3 and PC2 in the maturation of VGF precursor [J].
Trani, E ;
Giorgi, A ;
Canu, N ;
Amadoro, G ;
Rinaldi, AM ;
Halban, PA ;
Ferri, GL ;
Possenti, R ;
Schininà, ME ;
Levi, A .
JOURNAL OF NEUROCHEMISTRY, 2002, 81 (03) :565-574
[45]  
Wisor JP, 1997, J COMP NEUROL, V378, P229
[46]   Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and-2 [J].
Yamaguchi, Hideki ;
Sasaki, Kazuki ;
Satomi, Yoshinori ;
Shimbara, Takuya ;
Kageyama, Haruaki ;
Mondal, Muhtashan S. ;
Toshinai, Koji ;
Date, Yukari ;
Gonzalez, Luis J. ;
Shioda, Seiji ;
Takao, Toshifumi ;
Nakazato, Masamitsu ;
Minamino, Naoto .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (36) :26354-26360
[47]   Involvement of anteroventral third ventricular AMPA/kainate receptors in both hyperosmotic and hypovolemic AVP secretion in conscious rats [J].
Yamaguchi, Ken'ichi ;
Yamada, Takaho .
BRAIN RESEARCH BULLETIN, 2006, 71 (1-3) :183-192
[48]   PHASICALLY FIRING NEURONS IN THE SUPRAOPTIC NUCLEUS OF THE RAT HYPOTHALAMUS - IMMUNOCYTOCHEMICAL AND ELECTRO-PHYSIOLOGICAL STUDIES [J].
YAMASHITA, H ;
INENAGA, K ;
KAWATA, M ;
SANO, Y .
NEUROSCIENCE LETTERS, 1983, 37 (01) :87-92
[49]   Calcitonin and bone formation: a knockout full of surprises [J].
Zaidi, M ;
Moonga, BS ;
Abe, E .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (12) :1769-1771
[50]   Proteolytic processing in the secretory pathway [J].
Zhou, A ;
Webb, G ;
Zhu, XR ;
Steiner, DF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :20745-20748
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