Neuroendocrine regulatory peptide-1 and-2: Novel bioactive peptides processed from VGF

被引：23
作者：
Toshinai, K. [1 ]
Nakazato, M. [1 ]
机构：
[1] Miyazaki Univ, Fac Med, Div Internal Med, Miyazaki 8891692, Japan
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 11-12期
关键词：
Neuroendocrine regulatory peptide; vasopressin; hypothalamus; VGF; processing; feeding regulation; PROTEIN-COUPLED RECEPTORS; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA; FEEDING-BEHAVIOR; ANGIOTENSIN-II; GROWTH-FACTOR; ENCODING VGF; GENE; RAT; NEUROPEPTIDE;
D O I：
10.1007/s00018-009-8796-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuroendocrine regulatory peptides (NERP)-1 and NERP-2 are derived from distinct regions of VGF, a neurosecretory protein that was originally identified as a product of a nerve growth factor-responsive gene in rat PC12 cells. The amino acid length of human NERP-1 is 26, and that of rat NERP-1 is 25. Human and rat NERP-2 are both 38 amino acid peptides. NERPs colocalize with vasopressin in the storage granules of the paraventricular and supraoptic nuclei in the hypothalamus of both rats and humans. Administration of NERPs suppresses hypertonic saline- or angiotensin II-induced vasopressin release from the hypothalamus and pituitary. Thus, VGF is a precursor of multiple bioactive peptides with diverse neuroendocrine functions, and NERPs are novel hypothalamic peptides involved in the control of body fluid homeostasis by regulating vasopressin release.
引用
收藏
页码：1939 / 1945
页数：7
相关论文
共 50 条
[1]  
Alder J, 2003, J NEUROSCI, V23, P10800
[2]   TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity [J].
Bartolomucci, A. ;
La Corte, G. ;
Possenti, R. ;
Locatelli, V. ;
Rigamonti, A. E. ;
Torsello, A. ;
Bresciani, E. ;
Bulgarelli, I. ;
Rizzi, R. ;
Pavone, F. ;
D'Amato, F. R. ;
Severini, C. ;
Mignogna, G. ;
Giorgi, A. ;
Schinina, M. E. ;
Elia, G. ;
Brancia, C. ;
Ferri, G. -L. ;
Conti, R. ;
Ciani, B. ;
Pascucci, T. ;
Dell'Omo, G. ;
Muller, E. E. ;
Levi, A. ;
Moles, A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (39) :14584-14589
[3]   Vasopressin: Behavioral roles of an "original" neuropeptide [J].
Caldwell, Heather K. ;
Lee, Heon-Jin ;
Macbeth, Abbe H. ;
Young, W. Scott, III .
PROGRESS IN NEUROBIOLOGY, 2008, 84 (01) :1-24
[4]   Cloning, structural organization analysis, and chromosomal assignment of the human gene for the neurosecretory protein VGF [J].
Canu, N ;
Possenti, R ;
Ricco, AS ;
Rocchi, M ;
Levi, A .
GENOMICS, 1997, 45 (02) :443-446
[5]   Peptidomics of the pars intercerebralis-corpus cardiacum complex of the migratory locust, Locusta migratoria [J].
Clynen, E ;
Baggerman, G ;
Veelaert, D ;
Cerstiaens, A ;
Van der Horst, D ;
Harthoorn, L ;
Derua, R ;
Waelkens, E ;
De Loof, A ;
Schoofs, L .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (07) :1929-1939
[6]   The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity [J].
De Lecea, L ;
Kilduff, TS ;
Peyron, C ;
Gao, XB ;
Foye, PE ;
Danielson, PE ;
Fukuhara, C ;
Battenberg, ELF ;
Gautvik, VT ;
Bartlett, FS ;
Frankel, WN ;
van den Pol, AN ;
Bloom, FE ;
Gautvik, KM ;
Sutcliffe, JG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) :322-327
[7]   THE BIOSYNTHESIS OF NEUROPEPTIDES - PEPTIDE ALPHA-AMIDATION [J].
EIPPER, BA ;
STOFFERS, DA ;
MAINS, RE .
ANNUAL REVIEW OF NEUROSCIENCE, 1992, 15 :57-85
[8]   Calcitonin, angiotensin II and FPP significantly modulate mouse sperm function [J].
Fraser, LR ;
Pondel, MD ;
Vinson, GP .
MOLECULAR HUMAN REPRODUCTION, 2001, 7 (03) :245-253
[9]   Intravenous hypertonic NaCl acts via cerebral sodium-sensitive and angiotensinergic mechanisms to improve cardiac function in haemorrhaged conscious sheep [J].
Frithiof, Robert ;
Eriksson, Stefan ;
Bayard, Frida ;
Svensson, Tor ;
Rundgren, Mats .
JOURNAL OF PHYSIOLOGY-LONDON, 2007, 583 (03) :1129-1143
[10]  
GINESSI L, 1984, BIOCHEM BIOPH RES CO, V125, P199
12345