Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation

被引：136
作者：
Ruppert, S. M. [1 ]
Hawn, T. R. [2 ]
Arrigoni, A. [1 ]
Wight, T. N. [3 ]
Bollyky, P. L. [1 ]
机构：
[1] Stanford Univ, Sch Med, Div Infect Dis, Stanford, CA 94305 USA
[2] Univ Washington, Med Ctr, Div Allergy & Infect Dis, Seattle, WA 98195 USA
[3] Benaroya Res Inst, Matrix Biol Div, Seattle, WA 98101 USA
来源：
IMMUNOLOGIC RESEARCH | 2014年 / 58卷 / 2-3期
基金：
美国国家卫生研究院;
关键词：
Hyaluronan; Danger signals; DAMP; Integrity signal; CD44; ECM; REGULATORY T-CELLS; CHEMOKINE GENE-EXPRESSION; INDUCED LUNG INJURY; EXPERIMENTAL ARTHRITIS; EXTRACELLULAR-MATRIX; DANGER SIGNAL; IMMUNE-SYSTEM; CD44-HYALURONAN INTERACTIONS; MOUSE MACROPHAGES; CROSS-LINKING;
D O I：
10.1007/s12026-014-8495-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue catabolism and promotes inflammation via effects on Toll-like receptor signaling. Conversely, high-molecular weight HA is prevalent in uninjured tissues and is anti-inflammatory. We propose that the ability of high-molecular weight but not low-molecular weight HA to cross-link CD44 functions as a novel form of pattern recognition that recognizes intact tissues and communicates "tissue integrity signals" that promote resolution of local immune responses.
引用
收藏
页码：186 / 192
页数：7
相关论文
共 78 条
  • [21] Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44
    Firan, M
    Dhillon, S
    Estess, P
    Siegelman, MH
    [J]. BLOOD, 2006, 107 (02) : 619 - 627
  • [22] Föger N, 2000, EUR J IMMUNOL, V30, P2888
  • [23] FORRESTER JV, 1980, IMMUNOLOGY, V40, P435
  • [24] Fujii Y, 2003, FEBS LETT, V539, P45, DOI 10.1016/S0014-5793(03)00182-0
  • [25] Systemic administration of high-molecular weight hyaluronan stimulates wound healing in genetically diabetic mice
    Galeano, Mariarosaria
    Polito, Francesca
    Bitto, Alessandra
    Irrera, Natasha
    Campo, Giuseppe M.
    Avenoso, Angela
    Calo, Margherita
    Lo Cascio, Patrizia
    Minutoli, Letteria
    Barone, Mauro
    Squadrito, Francesco
    Altavilla, Domenica
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2011, 1812 (07): : 752 - 759
  • [26] Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis
    Gasse, Pamela
    Riteau, Nicolas
    Charron, Sabine
    Girre, Sandra
    Fick, Lizette
    Petrilli, Virginie
    Tschopp, Jueg
    Lagente, Vincent
    Quesniaux, Valerie F. J.
    Ryffel, Bernhard
    Couillin, Isabelle
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179 (10) : 903 - 913
  • [27] CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and-2
    Harada, Hosami
    Takahashi, Masaaki
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (08) : 5597 - 5607
  • [28] Hyaluronan minimizes effects of UV irradiation on human keratinocytes
    Hasova, Martina
    Crhak, Tomas
    Safrankova, Barbora
    Dvorakova, Jana
    Muthny, Tomas
    Velebny, Vladimir
    Kubala, Lukas
    [J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2011, 303 (04) : 277 - 284
  • [29] CD44 mobilization in allogeneic dendritic cell-T cell immunological synapse plays a key role in T cell activation
    Hegde, Venkatesh L.
    Singh, Narendra P.
    Nagarkatti, Prakash S.
    Nagarkatti, Mitzi
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (01) : 134 - 142
  • [30] Horton MR, 1998, J IMMUNOL, V160, P3023
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