Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation

被引：136
作者：
Ruppert, S. M. [1 ]
Hawn, T. R. [2 ]
Arrigoni, A. [1 ]
Wight, T. N. [3 ]
Bollyky, P. L. [1 ]
机构：
[1] Stanford Univ, Sch Med, Div Infect Dis, Stanford, CA 94305 USA
[2] Univ Washington, Med Ctr, Div Allergy & Infect Dis, Seattle, WA 98195 USA
[3] Benaroya Res Inst, Matrix Biol Div, Seattle, WA 98101 USA
来源：
IMMUNOLOGIC RESEARCH | 2014年 / 58卷 / 2-3期
基金：
美国国家卫生研究院;
关键词：
Hyaluronan; Danger signals; DAMP; Integrity signal; CD44; ECM; REGULATORY T-CELLS; CHEMOKINE GENE-EXPRESSION; INDUCED LUNG INJURY; EXPERIMENTAL ARTHRITIS; EXTRACELLULAR-MATRIX; DANGER SIGNAL; IMMUNE-SYSTEM; CD44-HYALURONAN INTERACTIONS; MOUSE MACROPHAGES; CROSS-LINKING;
D O I：
10.1007/s12026-014-8495-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue catabolism and promotes inflammation via effects on Toll-like receptor signaling. Conversely, high-molecular weight HA is prevalent in uninjured tissues and is anti-inflammatory. We propose that the ability of high-molecular weight but not low-molecular weight HA to cross-link CD44 functions as a novel form of pattern recognition that recognizes intact tissues and communicates "tissue integrity signals" that promote resolution of local immune responses.
引用
收藏
页码：186 / 192
页数：7
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